Antioxidant Activity and Anti-wrinkle Effects of Aceriphyllum rossii Leaf Ethanol Extract
TL;DR: It is concluded that ARLEE has excellent antioxidant activity and even better anti-wrinkle effects than ascorbic acid in human dermal fibroblasts and could be used in functional cosmetics for the prevention or alleviation of skin wrinkles induced by ultraviolet rays.
read more
Abstract: We evaluated the antioxidant activity and anti-wrinkle effects of Aceriphyllum rossii leaf ethanol extract (ARLEE) in vitro using human dermal fibroblasts. The total polyphenol and flavonoid contents of ARLEE were 578.6 and 206.3 mg/g, respectively. At a concentration of 250 μg/mL, the electron-donating ability of ARLEE was 87.1%. In comparison with the vehicle, ARLEE treatment at 100 μg/mL significantly increased type I procollagen synthesis (p < 0.01) by 50.7%. In vitro ARLEE treatment (10 mg/mL) inhibited collagenase and elastase activity by 97.1% and 99.2%, respectively. Compared with the control, ascorbic acid treatment at 100 μg/mL significantly decreased matrix metalloproteinase (MMP)-1 protein expression (p < 0.01) by 37.0%. ARLEE treatment at 50 μg/mL significantly decreased MMP-1 protein expression (p < 0.01) by 46.1%. Ascorbic acid and ARLEE treatments at 100 μg/mL significantly decreased MMP-1 mRNA expression (p < 0.01) by 26.1% and 36.1%, respectively. From these results, we conclude that ARLEE has excellent antioxidant activity and even better anti-wrinkle effects than ascorbic acid in human dermal fibroblasts. These results suggest that ARLEE could be used in functional cosmetics for the prevention or alleviation of skin wrinkles induced by ultraviolet rays.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Flavonoids as inhibitors of human neutrophil elastase.
TL;DR: In this paper, the authors focused on elastase inhibitors that have been discovered from natural sources and are biochemically characterised as flavonoids, and presented analysis of structure-activity relationship (SAR) enables the determination of the chemical groups responsible for evoking an inhibitory effect on ELASTase, which is a characteristic of aglycones and their glycoside and methylated, acetylated and hydroxylated derivatives.
59
Anti-Inflammatory, Barrier-Protective, and Antiwrinkle Properties of Agastache rugosa Kuntze in Human Epidermal Keratinocytes.
Yoonjin Lee,Hye-Won Lim,In Wang Ryu,Yu-Hua Huang,Minsik Park,Young Min Chi,Chang-Jin Lim,Chang-Jin Lim +7 more
TL;DR: Findings preliminarily imply that the leaves of A. rugosa possess desirable cosmetic potentials, such as anti-inflammatory, barrier protective, and antiwrinkle activities, which infers their skin healing potentials.
Anti-Photoaging Effects of Angelica acutiloba Root Ethanol Extract in Human Dermal Fibroblasts
TL;DR: It is suggested that Angelica acutiloba root ethanol extract may be a potentially effective agent for the prevention or alleviation of skin-wrinkle formation induced by ultraviolet rays.
Wrinkles: origins and treatments
Sara Bernardi
- 06 Apr 2016
TL;DR: The purpose of this review is to consider the wrinkles origin and the treatments that cosmetology and aesthetic medicine offered so far.
6
Antiphotoaging properties of Zingiber montanum essential oil isolated by solvent-free microwave extraction against ultraviolet B-irradiated human dermal fibroblasts
TL;DR: The essential oil of Z. montanum could have potential applications in developing cosmeceutical products to prevent skin photoaging and in a cell migration assay, the essential oil demonstrated wound-healing properties.
6
References
•Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
318.1K
Antioxidant Determinations by the Use of a Stable Free Radical
TL;DR: In this paper, the chemical nature of the antioxidant is known and a test specific for the compound or group of interest; for example, the nitroprusside test for sulphydryl groups.
12.9K
Mechanisms of photoaging and chronological skin aging
Gary J. Fisher,Sewon Kang,James Varani,Zsuzsanna Bata-Csorgo,Yinsheng Wan,Subhash C. Datta,John J. Voorhees +6 more
TL;DR: This article reviews the current understanding and presents new data about the molecular pathways that mediate skin damage by UV irradiation and by the passage of time and reveals that chronological aging and photoaging share fundamental molecular pathways.
1.6K
Changing Views of the Role of Matrix Metalloproteinases in Metastasis
TL;DR: A new view of the functional role of M MPs in metastasis is presented, which suggests that MMPs are important in creating and maintaining an environment that supports the initiation and maintenance of growth of primary and metastatic tumors.