Antimicrobial and Cytotoxic Activity of Three Bitter Plants-Enhydra Fluctuans, Andrographis Peniculata and Clerodendrum Viscosum.
TL;DR: Enhydra fluctuans and Andrographis peniculata possesses significant antimicrobial and cytotoxic activities.
read more
Abstract: Purpose: In this study, three important medicinal plants (Enhydra fluctuans Lour, Clerodendrum viscosum Vent and Andrographis peniculata Wall) of Bangladesh were investigated to analyze their antimicrobial and cytotoxic activities against some pathogenic microorganisms and Artemia salina (brine shrimp nauplii). Methods: The coarse powder material of leaves of each plant was extracted separately with methanol and acetone to yield methanol extracts of leaves of Enhydra fluctuans (MLE), Clerodendrum viscosum (MLC) and Andrographis peniculata (MLA), and acetone extracts of leaves of Enhydra fluctuans (ALE), Clerodendrum viscosum (ALC) and Andrographis peniculata (ALA). The disc diffusion method and the method described by Meyer were used to determine the antimicrobial and cytotoxic activities of each plant extract. Results: Among the test samples, MLE and ALE showed comparatively better antimicrobial activity against a number of bacteria and fungi with inhibition zones in the range of 06-15 mm and according to the intensity of activity, the efficacy against microorganisms were found in the order of Enhydra fluctuans > Andrographis peniculata > Clerodendrum viscosum. In cytotoxicity assay, all samples were found to be active against brine shrimp nauplii (Artemia salina) and ALA produced lowest LC50 value (7.03 μg/ml). Conclusion: Enhydra fluctuans and Andrographis peniculata possesses significant antimicrobial and cytotoxic activities.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Phytochemical and in vitro biological investigations of methanolic extracts of Enhydra fluctuans Lour.
Sourov Kuri,Md. Mustahsan Billah,S. M. Masud Rana,Zannatul Naim,Md. Mahmodul Islam,Md. Hasanuzzaman,Md. Ramjan Ali,Rana Banik +7 more
TL;DR: The study proves that the crude methanolic extract of Enhydra fluctuans Lour has significant antioxidant, anthelmintic and thrombolytic activity containing wide range of phytochemicals.
•Journal Article
Enhydra fluctuans Lour: A Review
TL;DR: The leaves extract of Enhydra fluctuans is an effective antibacterial against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Micrococcus luteus.
19
Ethnobotanical uses, phytochemistry and pharmacological activities of Clerodendrum infortunatum L. (Lamiaceae): A review
TL;DR: The traditional (ethnobotanical) uses and pharmacological activities displayed by C. infortunatum are discussed, revealing various pharmacological properties exhibited by the plant such as antimicrobial, antioxidant, analgesic, wound healing, antivenom, hepatoprotective, anti-inflammatory, antipyretic, anthelmintic, insecticidal, thrombolytic and cytotoxic activities.
Susceptibility of microorganism to selected medicinal plants in Bangladesh
S. M. Masud Rana,Md. Mustahsan Billah,Mohammad Salim Hossain,A. K. M. Saifuddin,S.K.M. Azizul Islam,Sujan Banik,Zannatul Naim,Golam Sarwar Raju +7 more
TL;DR: In-vitro antimicrobial activities of some ethno-pharmacologically significant medicinal plants (methanol extract) against the pathogenic microorganisms are analyzed to determine their full spectrum of efficacy.
17
Isolation and Structural Elucidation of Bioactive Compounds from Bangladeshi Medicinal Plants with a Focus on Novel Anticancer Compounds
Raushanara Akter
- 01 Jan 2014
TL;DR: The present study describes the bioactivity guided isolation and structural elucidation of novel anticancer compounds from the Bangladeshi medicinal plant Blumera lacera, found to be more cytotoxic and thus selected for bioassay-guided isolation of constituents.
15
References
Brine shrimp: a convenient general bioassay for active plant constituents.
Brian N. Meyer,Nelson R. Ferrigni,J. E. Putnam,Linda B. Jacobsen,David E. Nichols,Jerry L. McLaughlin +5 more
TL;DR: Screening results with seed extracts of 41 species of Euphorbiaceae were compared with 9KB and 9PS cytotoxicities and the method is rapid, reliable, inexpensive, and convenient as an in-house general bioassay tool.
4.8K
Antibacterial resistance worldwide: causes, challenges and responses.
Stuart B. Levy,Bonnie Marshall +1 more
TL;DR: The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics, and today, clinically important bacteria are characterized not only by single drug resistance but also by multiple antibiotic resistance.
A convenient general bioassay for active plant constituents
Brian N. Meyer,Nelson R. Ferrigni,J. E. Putnam,J B Jacobson,D E Nicholas,Jerry L. McLaughlin,B Shrimp +6 more
- 01 Jan 1982
TL;DR: In this article, a simple bioassay for natural product research using brine shrimp (Artemia salina leach) is proposed, which determines LC (50) values in microg/ml of active compounds and extracts in the brine medium.
3.6K
Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'.
TL;DR: This review provides a number of recommendations that will help to define a more sound 'proof-of-concept' for antibacterial, antifungal, antiviral and antiparasitic potential in natural products.
1.6K
Screening methods for natural products with antimicrobial activity: a review of the literature.
TL;DR: All the various techniques are reviewed here and, in order to unify the different criteria and parameters, standard methods to study the antimicrobial activity of medicinal plants are proposed.
943