Journal Article10.1142/S0192415X94000073
Antihypertensive property and renal protection by Shichimotsu-koka-to extract in salt-induced hypertension in Dahl strain rats
Nobuhito Hiwara,Yoshio Uehara,Satoru Takada,Yukari Kawabata,Nobuko Ohshima,Taiji Nagata,Toshihiko Ishimitsu,Tomoko Gomi,Atsuo Goto,Toshio Ikeda,Shigeru Yagi,Masao Omata +11 more
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TL;DR: The data suggest that Shichimotsukoka-to extract exhibits an antihypertensive effect which is associated with partial resolution of glomerular sclerosis in the kidney.
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Abstract: We determined whether or not the kampo formula, Shichimotsu-koka-to extract, attenuates the development of salt-induced hypertension and provides renal protection against hypertensive injury in Dahl salt-sensitive (Dahl S) rats. A six-week treatment using this formula dose-dependently decreased the systolic blood pressure in Dahl S rats fed a high-salt (2% NaCl) diet. This blood pressure reduction was associated with a decrease in the thickness of the aortic wall. Renal function was not altered with this treatment; however, glomerular sclerotic lesions in the kidney were significantly attenuated. Neither arterial nor tubular lesions were affected. These data suggest that Shichimotsu-koka-to extract exhibits an antihypertensive effect which is associated with partial resolution of glomerular sclerosis in the kidney.
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Inhibition of Angiotensin Converting Enzyme, Angiotensin II Receptor Blocking, and Blood Pressure Lowering Bioactivity across Plant Families
TL;DR: In vitro and in vivo reports of plant-derived extracts that inhibit ACE activity, block angiotensin II receptor binding and demonstrate hypotensive activity in animal or human studies are reviewed.
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Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by the DDAH-ADMA-NO pathway
TL;DR: It is considered that SKT reduced blood pressure in the renal hypertension rat model, mediated, at least partially, by the DDAH-ADMA-NO pathway.
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Suppressive effect of Shichimotsu-koka-to (Kampo medicine) on pulmonary metastasis of B16 melanoma cells.
TL;DR: It is suggested that macrophage function-modulating activity by SKT appears to underlie its antimetastatic activity, which leads to a decrease in the number of lung metastatic surface nodules and the extension of life span.
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Protective effects of Shichimotsu-koka-To on irreversible Thy-1 nephritis
TL;DR: It is suggested that Shichimotsu-koka-To may be useful for the treatment of CKD during the progression to nephrosclerosis, through the mechanisms of anti-oxidative activity and maintenance of PTC networks.
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The renoprotective effect of shichimotsukokato on hypertension-induced renal dysfunction in spontaneously hypertensive rats.
TL;DR: It is concluded that SKT administration significantly ameliorated this decrease in systolic blood pressure in spontaneously hypertensive rats, and the mechanism of SKT in reducing urinary albumin excretion is mediated, at least partly, by prevention of the loss of ClC-5 in the renal cortex of SHRs.
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