Antibacterial Therapeutic Agents Composed of Functional Biological Molecules
Dawei Li,Bing Zhou,Bei Lv +2 more
TL;DR: In this review, antimicrobial therapeutic agents composed of three kinds of functional biological molecules were summarized and the research progress of antibacterial mechanism, chemical modification, and nanoparticle coupling of those biomolecules were also discussed.
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Abstract: Antibacterial agents are a group of materials that selectively destroy bacteria by interfering with bacterial growth or survival. With the emergence of resistance phenomenon of bacterial pathogens to current antibiotics, new drugs are frequently entering into the market along with the existing drugs, and the alternative compounds with antibacterial functions are being explored. Due to the advantages of their inherent biochemical and biophysical properties including precise targeting ability, biocompatibility, biodegradability, long blood circulation time, and low cytotoxicity, biomolecules such as peptides, carbohydrates, and nucleic acids have huge potential for the antimicrobial application and have been extensively studied in recent years. In this review, antimicrobial therapeutic agents composed of three kinds of functional biological molecules were summarized. In addition, the research progress of antibacterial mechanism, chemical modification, and nanoparticle coupling of those biomolecules were also discussed.
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References
A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade.
Xiaoxia Liang,Wu Qiang,Shangxian Luan,Zhongqiong Yin,Changliang He,Lizi Yin,Yuanfeng Zou,Yuan Zhixiang,Lixia Li,Xu Song,Min He,Cheng Lv,Wei Zhang +12 more
TL;DR: This review summarizes types of topoisomerase inhibitors in the past decade, and divides them into nine classes by structural characteristics, including N-heterocycles compounds, quinone derivatives, flavonoids derivatives, coumarin derivatives, lignan derivatives, polyphenol derivatives, diterpenes derivatives, fatty acids derivatives, and metal complexes.
184
Thermodynamic, counterion, and hydration effects for the incorporation of locked nucleic acid nucleotides into DNA duplexes.
TL;DR: This work evaluated the hybridization thermodynamics of a series of LNA-substituted DNA octamers, modified to various extents by one to three LNA substitutions, introduced at either adenine ( 5'-AGCACCAG) or thymine (5'-TGCTCCTG) nucleotides.
180
Antimicrobial peptides: Possible anti-infective agents.
TL;DR: This review outlines selected anion and cationic AMPs which are at various stages of development, from preliminary analysis to clinical drug development, and considers current production methods and delivery tools for AMPs, which must be improved for the effective use of these agents.
177
New antimicrobial chitosan derivatives for wound dressing applications.
Oana Maria Dragostin,Sangram Keshari Samal,Mamoni Dash,Florentina Lupascu,Andreea Pânzariu,Cristina Tuchilus,Nicolae Ghetu,Mihai Danciu,Peter Dubruel,Dragos Pieptu,Cornelia Vasile,Rodica Tatia,Lenuta Profire +12 more
TL;DR: The MTT assay showed that some of chitosan derivatives are nontoxic, and the in vivo study on burn wound model induced in Wistar rats demonstrated an improved healing effect and enhanced epithelialization of ch itosan-sulfonamide derivatives compared to neat chitOSan.
175
Insect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteria.
Mohammad Rahnamaeian,Małgorzata Cytryńska,Agnieszka Zdybicka-Barabas,Kristin Dobslaff,Jochen Wiesner,Richard M. Twyman,Thole Zuchner,Ben M. Sadd,Roland R. Regoes,Paul Schmid-Hempel,Andreas Vilcinskas +10 more
TL;DR: The potentiating functional interaction of co-occurring insect AMPs (the bumblebee linear peptides hymenoptaecin and abaecin) resulting in more potent antimicrobial effects at low concentrations suggest that combinations of AMPs could be used therapeutically against Gram-negative bacterial pathogens that have acquired resistance to common antibiotics.
169