Journal Article10.1021/LA800951V
Antibacterial Effects of Carbon Nanotubes: Size Does Matter!
1.1K
TL;DR: It is provided the first evidence that the size (diameter) of carbon nanotubes (CNTs) is a key factor governing their antibacterial effects and that the likely main CNT-cytotoxicity mechanism is cell membrane damage by direct contact with CNTs.
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Abstract: We provide the first evidence that the size (diameter) of carbon nanotubes (CNTs) is a key factor governing their antibacterial effects and that the likely main CNT-cytotoxicity mechanism is cell membrane damage by direct contact with CNTs. Experiments with well-characterized single-walled carbon nanotubes (SWNTs) and multiwalled carbon nanotubes (MWNTs) demonstrate that SWNTs are much more toxic to bacteria than MWNTs. Gene expression data show that in the presence of both MWNTs and SWNTs, Escherichia coli expresses high levels of stress-related gene products, with the quantity and magnitude of expression being much higher in the presence of SWNTs.
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Exposure to Carbon Nanotube Material: Assessment of Nanotube Cytotoxicity using Human Keratinocyte Cells
Anna A. Shvedova,Vincent Castranova,Elena R. Kisin,Diane Schwegler-Berry,Ashley R. Murray,Vadim Z Gandelsman,Andrew D. Maynard,Paul Baron +7 more
TL;DR: Investigation of adverse effects of single-wall carbon nanotubes using a cell culture of immortalized human epidermal keratinocytes indicates that dermal exposure to unrefined SWCNT may lead to dermal toxicity due to accelerated oxidative stress in the skin of exposed workers.
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