Anti-inflammatory and immunomodulatory effects of statins
TL;DR: The anti-inflammatory and immunomodulatory effects of statins and their participation in the different steps of atherosclerotic lesion formation are summarized.
read more
About: This article is published in Kidney International. The article was published on 01 Jan 2003. and is currently open access. The article focuses on the topics: HMG-CoA reductase.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Inflammation and atherosclerosis
TL;DR: In this paper, the authors describe the inflammatory process of atherosclerosis, which occurs when cholesterol-containing low-density lipoproteins accumulate in the intima and activate the endothelium.
1K
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease.
Alan Chait,Laura J. den Hartigh +1 more
TL;DR: The mechanisms by which dysfunctional adipose tissue simultaneously promote T2DM and CVD, focusing on adipose tissues depot-specific adipokines, inflammatory profiles, and metabolism, will be the focus of this review.
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
TL;DR: The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular reactive oxygen species (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive as discussed by the authors.
Repository
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
TL;DR: It is argued that the role of poorly liganded iron has been rather underappreciated in the past, and that in combination with peroxide and superoxide its activity underpins the behaviour of a great many physiological processes that degrade over time.
493
Prior Statin Therapy Is Associated With a Decreased Rate of Severe Sepsis
Yaniv Almog,Alexander Shefer,Victor Novack,Nimrod Maimon,Leonid Barski,Miruna Eizinger,Michael Friger,Lior Zeller,Abraham Danon +8 more
TL;DR: Prior therapy with statins may be associated with a reduced rate of severe sepsis and intensive care unit (ICU) admission and statin treatment may have a role in the primary prevention of septicaemia.
440
References
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
21.2K
Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
5.7K
Regulation of the mevalonate pathway.
TL;DR: The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control, and could be useful in treating certain forms of cancer as well as heart disease.
5.5K