Patent
Anti-angiogenic compositions and methods of use
William L. Hunter,Lindsay S. Machan,A. Larry Arsenault +2 more
- 19 Jul 1994
1.2K
TL;DR: In this article, an anti-angiogenic factor and a polymeric carrier were used for embolization of blood vessels and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
read more
Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
Compositions and coatings for implantable medical devices
Vandana B. Patravale,Devesh Kothwala,Ankur Raval +2 more
- 08 Mar 2007
TL;DR: An implantable medical device, comprising a polymer coated on at least a portion of the medical device and a pharmaceutically active agent covalently bonded to the polymer, is defined in this paper.
45
Patent
Biocompatible polyacrylate compositions for medical applications
Syed F. A. Hossainy
- 25 Mar 2005
TL;DR: In this article, a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymer having an acrylate moiety and a Bioben-eficial moiety is disclosed.
45
Patent
Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation
Gary K. Owens,Whye-Kei Lye,Michael L. Reed,Joshua Spradlin,Brian R. Wamhoff,Matthew Hudson,Kareen Looi +6 more
- 24 May 2007
TL;DR: In the case of stents, the nanoporous layer promotes re-endothelialization at sites of stent implantation vasculature, improves overall healing, and reduces inflammation and intimal disease progression.
45
Patent
Poly(ester amide) filler blends for modulation of coating properties
Jessica Renee Desnoyer,Stephen D. Pacetti,Syed Faiyaz Shmed Hossainy,Lothar W. Kleiner,Yiwen Tang,Gina Zhang +5 more
- 21 Oct 2005
TL;DR: In this paper, a PEA polymer blend and a material capable of hydrogen bonding with the PEA can be used to form a coating on an implantable device, one example of which is a stent.
45
Patent
Implants with controlled drug delivery features and methods of using same
David Haffner,Thomas W. Burns,Harold A. Heitzmann,Kenneth M. Curry +3 more
- 10 Mar 2014
TL;DR: In this article, drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder are presented.
45
References
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
11.4K
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
TL;DR: It is shown that vascular endothelial growth factor (VEGF) probably functions as a hypoxia-inducible angiogenic factor and is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci and the clustering of capillaries alongside VEGF-producing cells.
4.9K
A Comparison of Balloon-Expandable-Stent Implantation with Balloon Angioplasty in Patients with Coronary Artery Disease
Patrick W. Serruys,P. de Jaegere,Ferdinand Kiemeneij,Carlos Macaya,Wolfgang Rutsch,Gr. Heyndrickx,H. Emanuelsson,Jean Marco,Victor Legrand,P. Materne +9 more
TL;DR: The clinical and angiographic outcomes were better in patients who received a stent than in those who received standard coronary angioplasty, however, this benefit was achieved at the cost of a significantly higher risk of vascular complications at the access site and a longer hospital stay.
A Randomized Comparison of Coronary-Stent Placement and Balloon Angioplasty in the Treatment of Coronary Artery Disease
David L. Fischman,Martin B. Leon,Donald S. Baim,Richard A. Schatz,Michael P. Savage,Ian M. Penn,Katherine D. Detre,Lisa Veltri,Donald R. Ricci,Masakiyo Nobuyoshi,Michael W. Cleman,Richard R. Heuser,David Almond,Paul S. Teirstein,R. David Fish,Antonio Colombo,Jeffrey C. Brinker,Jeffrey Moses,Alex Shaknovich,John N. Hirshfeld,Stephen Bailey,Stephen E. Ellis,Randal Rake,Sheldon Goldberg +23 more
TL;DR: In selected patients, placement of an intracoronary stent, as compared with balloon angioplasty, results in an improved rate of procedural success, a lower rate of angiographically detected restenosis, a similar rate of clinical events after six months, and a less frequent need for revascularization of the original coronary lesion.
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
4.2K
Related Papers (5)
Ni Ding,Michael N. Helmus +1 more
- 19 Jun 1998
Eric P. Berg,Ronald J. Tuch,Michael Dror,Rodney G. Wolff +3 more
- 07 Jun 1995