Patent
Anti-angiogenic compositions and methods of use
William L. Hunter,Lindsay S. Machan,A. Larry Arsenault +2 more
- 19 Jul 1994
1.2K
TL;DR: In this article, an anti-angiogenic factor and a polymeric carrier were used for embolization of blood vessels and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
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Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
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Citations
Patent
Compositions and methods for treating or preventing diseases of body passageways
William L. Hunter,Lindsay S. Machan +1 more
- 21 Oct 2004
TL;DR: In this article, the authors present methods for treating or preventing diseases associated with body passageways, comprising the step of delivering to an external portion of the body passage a therapeutic agent.
377
Patent
Coating composition for multiple hydrophilic applications
Schottman Thomas C,Hennessey Patrick M,Gruening Rainer +2 more
- 31 Mar 2003
TL;DR: In this paper, a coating composition consisting of an aqueous polymeric matrix, a hydrophilic polymer, a colloidal metal oxide and a crosslinker was disclosed.
374
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Drug release coated stent
Ni Ding,Michael N. Helmus +1 more
- 01 Apr 1996
TL;DR: In this article, a stent for implantation in a body lumen location of interest in a patient is described, which includes a generally flexible elastic, tubular body (10) having open ends and a thin open porous sidewall structure.
372
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Expandable medical device for delivery of beneficial agent
John F. Shanley
- 21 Sep 2001
TL;DR: In this paper, a plurality of elongated struts are joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder with a second diameter, and a beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent.
372
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Expandable medical device with ductile hinges
John F. Shanley
- 26 Mar 1999
TL;DR: In this article, an expandable tissue supporting device employs ductile hinges at selected points in the expandable device to concentrate expansion stresses and strains in small well defined areas when expansion forces are applied to the device as a whole.
372
References
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
TL;DR: It is shown that vascular endothelial growth factor (VEGF) probably functions as a hypoxia-inducible angiogenic factor and is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci and the clustering of capillaries alongside VEGF-producing cells.
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A Comparison of Balloon-Expandable-Stent Implantation with Balloon Angioplasty in Patients with Coronary Artery Disease
Patrick W. Serruys,P. de Jaegere,Ferdinand Kiemeneij,Carlos Macaya,Wolfgang Rutsch,Gr. Heyndrickx,H. Emanuelsson,Jean Marco,Victor Legrand,P. Materne +9 more
TL;DR: The clinical and angiographic outcomes were better in patients who received a stent than in those who received standard coronary angioplasty, however, this benefit was achieved at the cost of a significantly higher risk of vascular complications at the access site and a longer hospital stay.
A Randomized Comparison of Coronary-Stent Placement and Balloon Angioplasty in the Treatment of Coronary Artery Disease
David L. Fischman,Martin B. Leon,Donald S. Baim,Richard A. Schatz,Michael P. Savage,Ian M. Penn,Katherine D. Detre,Lisa Veltri,Donald R. Ricci,Masakiyo Nobuyoshi,Michael W. Cleman,Richard R. Heuser,David Almond,Paul S. Teirstein,R. David Fish,Antonio Colombo,Jeffrey C. Brinker,Jeffrey Moses,Alex Shaknovich,John N. Hirshfeld,Stephen Bailey,Stephen E. Ellis,Randal Rake,Sheldon Goldberg +23 more
TL;DR: In selected patients, placement of an intracoronary stent, as compared with balloon angioplasty, results in an improved rate of procedural success, a lower rate of angiographically detected restenosis, a similar rate of clinical events after six months, and a less frequent need for revascularization of the original coronary lesion.
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
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