Animal models for COVID-19.
César Muñoz-Fontela,William E. Dowling,Simon G. P. Funnell,Pierre Stéphane Gsell,A. Ximena Riveros-Balta,Randy A. Albrecht,Hanne Leth Andersen,Ralph S. Baric,Miles W. Carroll,Marco Cavaleri,Chuan Qin,Ian Crozier,Kai Dallmeier,Leon de Waal,Emmie de Wit,Leen Delang,Erik D. Dohm,W. Paul Duprex,Darryl Falzarano,Courtney L. Finch,Matthew B. Frieman,Barney S. Graham,Lisa E. Gralinski,Kate Guilfoyle,Bart L. Haagmans,Geraldine A. Hamilton,Amy L. Hartman,Sander Herfst,Suzanne J.F. Kaptein,William B. Klimstra,Ivana Knezevic,Philip R. Krause,Jens H. Kuhn,Roger Le Grand,Mark G. Lewis,Wen-Chun Liu,Pauline Maisonnasse,Anita K. McElroy,Vincent J. Munster,Nadia Oreshkova,Angela L. Rasmussen,Joana Rocha-Pereira,Barry Rockx,Estefanía Rodríguez,Thomas F. Rogers,Francisco J. Salguero,Michael Schotsaert,Koert J. Stittelaar,Hendrik Jan Thibaut,Chien Te K. Tseng,Júlia Vergara-Alert,Martin Beer,Trevor Brasel,Jasper Fuk-Woo Chan,Adolfo García-Sastre,Johan Neyts,Stanley Perlman,Douglas S. Reed,Juergen A. Richt,Chad J. Roy,Joaquim Segalés,Seshadri S. Vasan,Seshadri S. Vasan,Ana Maria Henao-Restrepo,Dan H. Barouch +64 more
TL;DR: The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.
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Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.
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Citations
Hamsters as a Model of Severe Acute Respiratory Syndrome Coronavirus-2.
Alicia M. Braxton,Patrick S. Creisher,Camilo A. Ruiz-Bedoya,Katie R Mulka,Santosh Dhakal,Alvaro A. Ordonez,Sarah E. Beck,Sanjay K. Jain,Jason S Villano +8 more
TL;DR: In this article, the authors describe key findings from studies of hamsters infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and highlight areas that need further investigation.
Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants
Lianghui Zhang,Soumajit Dutta,Shiqin Xiong,Matthew Chan,Kui K Chan,Timothy M Fan,Keith L Bailey,Matthew Lindeblad,Laura M Cooper,Lijun Rong,Anthony F Gugliuzza,Diwakar Shukla,Erik Procko,Jalees Rehman,Asrar B Malik +14 more
TL;DR: Engineered ACE2 peptide with high affinity for SARS-CoV-2 Spike protein shows broad efficacy against multiple viral variants, preventing ARDS and death in humanized mice, offering a promising therapeutic option for COVID-19 treatment.
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Sushmita Roy,Bhuiyan Mohammad Mahtab Uddin,Iftikhar Ahmed +2 more
TL;DR: Emergence of SARS-CoV-2 variants correlates with increased COVID-19 cases, potentially evading vaccine immunity, necessitating genomic surveillance, and urgent global response with reliable scientific evidence to inform public health interventions and vaccination policies.
Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets
Rory D. de Vries,Katharina S. Schmitz,Francesca T. Bovier,Francesca T. Bovier,Danny Noack,Bart L. Haagmans,Sudipta Biswas,Barry Rockx,Samuel H. Gellman,Christopher A. Alabi,Rik L. de Swart,Anne Moscona,Matteo Porotto,Matteo Porotto +13 more
TL;DR: A dimeric lipopeptide fusion inhibitor is designed that blocks this critical first step of infection for emerging coronaviruses and it completely prevents SARS-CoV-2 infection in ferrets, and is a potent inhibitor of fusion and infection in vitro and transmission in vivo.
ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7.
Robert J. Fischer,Neeltje van Doremalen,Danielle R. Adney,Claude Kwe Yinda,Julia R Port,Myndi G. Holbrook,Jonathan E Schulz,Brandi N. Williamson,Tina Thomas,Kent D. Barbian,Sarah L. Anzick,Stacy M. Ricklefs,Brian J. Smith,Dan Long,Craig Martens,Greg Saturday,Emmie de Wit,Sarah C. Gilbert,Teresa Lambe,Vincent J. Munster +19 more
TL;DR: In this paper, the ChAdOx1 nCoV-19 (AZD1222) vaccine efficacy against SARS-CoV2 variants of concern (VOCs) B.1.7 and B.351 in Syrian hamsters was investigated.
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