Journal Article10.1016/J.BIOMATERIALS.2011.02.044
Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma.
Hongliang Xin,Xinyi Jiang,Jijin Gu,Xianyi Sha,Liangcen Chen,Kitki Law,Yanzuo Chen,Xiao Wang,Ye Jiang,Xiaoling Fang +9 more
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TL;DR: Angiopep-conjugated PEG-PCL nanoparticles were prospective in dual-targeting drug delivery system for targeting therapy of brain glioma because of their ability to target the low-density lipoprotein receptor-related protein (LRP) which is over-expressed on the Blood-brain barrier andglioma cells.
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About: This article is published in Biomaterials. The article was published on 01 Jun 2011. The article focuses on the topics: Nanoparticles for drug delivery to the brain & Glioma.
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Citations
The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2.
Jinfeng Ren,Shun Shen,Dangge Wang,Zhangjie Xi,Liangran Guo,Zhiqing Pang,Yong Qian,Xiyang Sun,Xinguo Jiang +8 more
TL;DR: O-MWNTs-PEG-ANG is a promising dual-targeting carrier to deliver DOX for the treatment of brain tumor and suggests a lower cardiac toxicity than DOX.
349
Multifunctional nanoparticles for brain tumor imaging and therapy.
TL;DR: The diagnostic and therapeutic applications of nanoparticles for brain tumors with an emphasis on innovative approaches in tumor targeting, tumor imaging, and therapeutic agent delivery are discussed and barriers towards clinical implementation of multifunctional nanoparticles are addressed.
312
Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles
Shaobo Ruan,Mingqing Yuan,Li Zhang,Guanlian Hu,Jiantao Chen,Xingli Cun,Qianyu Zhang,Yuting Yang,Qin He,Huile Gao +9 more
TL;DR: In conclusion, An-PEG-DOX-AuNPs could specifically deliver and release DOX in glioma and significantly expand the median survival time ofglioma-bearing mice.
306
Dual-targeting upconversion nanoprobes across the blood-brain barrier for magnetic resonance/fluorescence imaging of intracranial glioblastoma.
Dalong Ni,Jiawen Zhang,Wenbo Bu,Huaiyong Xing,Fang Han,Qingfeng Xiao,Zhenwei Yao,Feng Chen,Qianjun He,Jianan Liu,Shengjian Zhang,Wenpei Fan,Liangping Zhou,Weijun Peng,Jianlin Shi +14 more
TL;DR: A dual-targeting nanoprobe (ANG/PEG-UCNPs) to cross the BBB, target the glioblastoma, and then function as a simultaneous MR/NIR-to-NIR UCL bimodal imaging agent, which showed a much enhanced imaging performance in comparison with the clinically used single MRI contrast and fluorescent dye.
301
Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles
TL;DR: Results indicate that Angiopep-conjugated dual targeting PEG-PCL nanoparticle is a potential brain targeting drug delivery system for glioma treatment.
295
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