Journal Article10.1016/J.BIOMATERIALS.2011.02.044
Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma.
Hongliang Xin,Xinyi Jiang,Jijin Gu,Xianyi Sha,Liangcen Chen,Kitki Law,Yanzuo Chen,Xiao Wang,Ye Jiang,Xiaoling Fang +9 more
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TL;DR: Angiopep-conjugated PEG-PCL nanoparticles were prospective in dual-targeting drug delivery system for targeting therapy of brain glioma because of their ability to target the low-density lipoprotein receptor-related protein (LRP) which is over-expressed on the Blood-brain barrier andglioma cells.
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About: This article is published in Biomaterials. The article was published on 01 Jun 2011. The article focuses on the topics: Nanoparticles for drug delivery to the brain & Glioma.
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Citations
Progress and perspectives on targeting nanoparticles for brain drug delivery.
TL;DR: In this review, the barriers to brain-targeted drug delivery are reviewed, including the BBB, blood–brain tumor barrier (BBTB), and nose-to-brain barrier, and delivery strategies are focused on overcoming theBBB, directly targeting diseased cells in the brain, and dual- targeted delivery.
448
Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier
Yutaka Miura,Tomoya Takenaka,Kazuko Toh,Shourong Wu,Hiroshi Nishihara,Mitsunobu R. Kano,Yasushi Ino,Takahiro Nomoto,Yu Matsumoto,Hiroyuki Koyama,Horacio Cabral,Nobuhiro Nishiyama,Kazunori Kataoka +12 more
TL;DR: It is likely that the selective and accelerated accumulation of cRGD/m into tumors occurred via an active internalization pathway, possibly transcytosis, thereby producing significant antitumor effects in an orthotopic mouse model of U87MG human glioblastoma.
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Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications
TL;DR: A comprehensive overview of the key sequences and structures utilised to provide biological and physical stability to nano-constructs, direct particles to their target and influence their cellular and tissue distribution, induce and control biological responses, and form polypeptide self-assembled nanoparticles are provided.
PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application.
TL;DR: This review discusses state‐of‐the‐art nanomedicines based on PEG‐PCL that have been investigated in a preclinical setting and highlights recent therapeutic applications investigated in vitro and in vivo using advanced systems such as triggered release, multi‐component therapies, theranostics, or gene delivery systems.
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Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment.
TL;DR: MNP-MSN-PLGA-Tf NPs are promising carriers for the delivery of dual drugs for effective treatment of brain glioma and could be enhanced by the presence of magnetic field and the usage of Tf as targeting ligand.
357
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