Book Chapter10.1007/978-3-662-00814-0_12
Androgens and human benign prostatic hyperplasia (BPH)
Michael Krieg,Sabine Tunn +1 more
- 01 Jan 1990
- pp 219-244
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TL;DR: There is strong physiological evidence that the development, integrity and secretory function of the human prostate are largely under the control of functioning testes.
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Abstract: The etiology of human benign prostatic hyperplasia (BPH) is poorly understood. However, as reviewed in detail in various chapters of Hinman’s monograph on benign prostatic hypertrophy (Hinman 1983) there is strong physiological evidence that the development, integrity and secretory function of the human prostate are largely under the control of functioning testes. Moreover, early clinical experience (Huggins and Stevens 1940) and histological data (Wendel 1972) indicate that castration induces regressive alterations in the epithelial compartment of established BPH. It has also been shown that canine BPH can be induced by androgens (Walsh and Wilson 1976; DeKlerk et al. 1979; Moore et al. 1979a).
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Citations
Prostate volume in testosterone‐treated and untreated hypogonadal men in comparison to age‐matched normal controls
TL;DR: The potential use of testosterone preparations for substitution therapy for ageing men and for male contraception, and the effect of testosterone therapy on the prostate in hypogonadal men are studied.
326
Effect of aging on endogenous level of 5 alpha-dihydrotestosterone, testosterone, estradiol, and estrone in epithelium and stroma of normal and hyperplastic human prostate.
TL;DR: The results indicate that the prostatic accumulation of DHT, estradiol, and estrone is in part intimately correlated with aging, leading with increasing age to a dramatic increase of the estrogen/androgen ratio particularly in stroma of BPH.
Effects of the Sabal serrulata extract IDS 89 and its subfractions on 5α‐reductase activity in human benign prostatic hyperplasia
TL;DR: It was found that the extract IDS 89 of Sabal serrulata inhibited dose dependently 5α‐reductase activity in the epithelium and stroma of human BPH, the mean inhibition being 29% and 45%, respectively.
85
Pharmacology and clinical uses of testosterone
Eberhard Nieschlag,Hermann M. Behre +1 more
- 01 Jan 1998
TL;DR: The first experimental proof that the testes produce a substance responsible for virility was provided by Berthold (1849) and is generally considered the origin of experimental endocrinology (Simmer and Simmer 1961).
55
Potential activities of androgen metabolizing enzymes in human prostate.
TL;DR: 5 alpha-reductase is the outstanding androgen metabolizing enzyme in NPR and BPH; dictating the DHT enrichment in the prostate; under the impact of aging; and preferentially inhibited by finasteride in E.
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References
The Development of Human Benign Prostatic Hyperplasia with Age
TL;DR: The prevalence and growth rate of human benign prostatic hyperplasia with age is reported by combining and analyzing data from 10 independent studies containing more than 1,000 prostates.
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Cloning of human androgen receptor complementary DNA and localization to the X chromosome.
Dennis B. Lubahn,David R. Joseph,Patrick Sullivan,Huntington F. Willard,Frank S. French,Elizabeth M. Wilson +5 more
TL;DR: The deduced amino acid sequence of AR within the DNA-binding domain has highest sequence identity with the progesterone receptor.
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Loss of circadian rhythmicity in blood testosterone levels with aging in normal men.
TL;DR: A clear decrease in serum testosterone levels in healthy old men compared to those in young men is demonstrated and this results provide an explanation for the inability to demonstrate an age-related decline inosterone levels in earlier studies using serum samples obtained in the afternoon.
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•Journal Article
Origin and evolution of benign prostatic enlargement.
TL;DR: Quantitative analysis was applied to BPH development in 63 autopsy prostates, finding that BPH evolved through three processes: early diffuse gland growth, small nodule proliferation, and later nodule enlargement.
564
Regulation of Androgen Action
Arun K. Roy,Yan Lavrovsky,Chung-Seog Song,Shuo Chen,Myeong H. Jung,N. K. Velu,B. Y. Bi,Bandana Chatterjee +7 more
TL;DR: This chapter describes the different aspects of regulation of androgen action, a member of the steroid-thyroid hormone-retinoid-vitamin D superfamily of nuclear receptors (NRs) that function as ligand-activated transcription factors.
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