Open AccessDissertation
Analysis of the molecular interactions regulating murine B cell development
Angela Stoddart
- 01 Jan 2000
About: The article was published on 01 Jan 2000. and is currently open access.
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References
Stimulation of B-cell progenitors by cloned murine interleukin-7.
Anthony E. Namen,Stephen D. Lupton,Kathryn A. Hjerrild,Janis M. Wignall,Diane Y. Mochizuki,Ann E. Schmierer,Bruce Mosley,Carl J. March,David L. Urdal,Steven Gillis,David Cosman,Raymond G. Goodwin +11 more
TL;DR: A bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors and a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7 is isolated.
861
Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav
Jaewon Han,Katherine Luby-Phelps,Balaka Das,Xiaodong Shu,Yi Xia,Raymond D. Mosteller,U. Murali Krishna,John R. Falck,Michael A. White,Daniel Broek +9 more
TL;DR: Control of Vav in response to mitogens by the products of PI 3-kinase suggests a mechanism for Ras-dependent activation of Rac.
848
The structural basis of the activation of Ras by Sos
TL;DR: The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 Å resolution and shows a structure that allows nucleotide release and rebinding.
814
Defective B cell development and function in Btk-deficient mice
Wasif N. Khan,Frederick W. Alt,Rachel M. Gerstein,Barbara A. Malynn,Irene Larsson,Gary Rathbun,Laurie Davidson,Sussane Müller,Aaron B. Kantor,Leonora A. Herzenberg,Fred S. Rosen,Paschalis Sideras +11 more
TL;DR: Results prove that lack of Btk function results in an Xid phenotype and further suggest a differential requirement for Btk during the early stages of murine versus human B lymphocyte development.
793
Perinatal lethality and blocked b-cell development in mice lacking the tyrosine kinase syk
Martin R Turner,P. J. Mee,P. S. Costello,Owen Williams,A. A. Price,L. P. Duddy,M. T. Furlong,Robert L. Geahlen,Victor L. J. Tybulewicz +8 more
TL;DR: It is shown that Syk is not required for signalling through the IL-2 and G-CSF receptors, and a possible role for this protein in the production or maintenance of mature B cells is suggested.
763