Open AccessDissertation
Analysis of the molecular interactions regulating murine B cell development
Angela Stoddart
- 01 Jan 2000
About: The article was published on 01 Jan 2000. and is currently open access.
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References
Hyperresponsive B Cells in CD22-Deficient Mice
TL;DR: CD22 is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering.
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Administration of human recombinant IL-7 to normal and irradiated mice increases the numbers of lymphocytes and some immature cells of the myeloid lineage.
TL;DR: Although the major in vivo effects of rhuIL-7 were on cells of the lymphocytic lineage, rhuil-7 also increased the numbers of some immature cells ofThe myeloid lineage.
Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains.
TL;DR: It is shown that both forms of the mu chain differ in their intracellular transport in pre‐B cells, which indicates that V kappa gene rearrangement seems to occur only in mu‐positive pre-B cells.
Differential roles of stromal cells, interleukin-7, and kit-ligand in the regulation of B lymphopoiesis
Linda G. Billips,Debra Petitte,Kenneth Dorshkind,Ramaswamy Narayanan,Choy-Pik Chiu,Kenneth S. Landreth +5 more
TL;DR: The experiments show that the stromal cell line S17 potentiates the proliferative effect of IL-7 on B-lineage cells and that this S17-derived potentiator can be replaced with recombinant kit-ligand (KL).
Cells and Molecules that Regulate B Lymphopoiesis in Bone Marrow
TL;DR: This review focuses on cells of the humoral immune system and those steps involved in their formation that can be observed and manipulated in culture and the probable source of such regulatory substances is becoming clearer.