Analysis of the molecular interactions regulating murine B cell development

TL;DR: It was demonstrated by antibody blockade to either CD11a, CD18 or CD54 that aggregation could be inhibited without affecting induced DNA synthesis or differentiation and that IL‐4 alone was able to induce aggregation of B‐CLL cells and to strongly enhance TPA+BSF‐MP6‐induced aggregalion.

TL;DR: It is concluded that CD45 expression on B lymphocytes is not essential for B cell responses following antigen stimulation in vivo, however, CD4+ T helper function was severely diminished in CD45 exon 6‐deficient mice, suggesting that the requirements of CD45 molecules in antigen‐specific response and development are different between T and B lymphocyte.

TL;DR: It is shown here that in conventional gamma 2b mice, B cell development actually arrests later, at the pre-B cell stage, which shows for the first time that a constant region different from mu can allow signaling through the pre -B cell receptor, but cannot promote complete development.

TL;DR: A predominance of multi-antennary structures was observed in the more glycosylated pathological immunoglobulins M (10% carbohydrate content), whereas oligomannosidic structures were increased in pathological Immunoglobulin M with a lower content of carbohydrates (7%).