Open AccessBook
Analysis of Human Genetic Linkage
Jurg Ott
- 01 May 1985
TL;DR: The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping as discussed by the authors, as well as practical comments on available computer programs and websites.
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Abstract: The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites. Each chapter ends with a set of problems, whose solutions are found at the end of the book. New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of nonparametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits. Although the book's primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.
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Citations
Genetic variation among different morphotypes of the male freshwater prawn Macrobrachium rosenbergii (De Man)
Mst. Rubia Banu,Siti Shapor Siraj,Annie Christianus,Natrah Fatin Mohd Ikhsan,Amy Halimah Rajaee +4 more
TL;DR: The pair-wise comparisons and the F ST values revealed significant genetic differentiation across the groups and the greatest genetic distance was observed between the BC and SM groups and lowest one was between theBC and the OC groups.
8
Exclusion of linkage between familial Mediterranean fever and the human serum amyloid A (SAA) gene cluster.
George H. Sack,C. Conover Talbot,Bruce G. McCarthy,Emily L. Harris,Daniel L. Kastner,Luis Gruberg,Mordechai Pras +6 more
TL;DR: The relationship between the autosomal recessive trait familial Mediterranean fever (FMF) and the serum amyloid A (SAA) genes is studied by comparing alleles of a highly polymorphic dinucleotide repeat and a conventional restriction fragment length polymorphism in the SAA gene cluster in Israeli FMF kindreds.
8
An Accurate Method for Inferring Relatedness in Large Datasets of Unphased Genotypes via an Embedded Likelihood-Ratio Test
Jesse M. Rodriguez,Serafim Batzoglou,Sivan Bercovici +2 more
- 07 Apr 2013
TL;DR: To enable disease-mapping studies of increasingly large cohorts, a fast and accurate method to detect IBD segments is required.
8
Predictability of heterozygosity scores and polymorphism information content values for rat genetic markers.
TL;DR: While the correlation of the indices between the two groups of animals is low, these indices do provide a means of predicting whether a genetic marker will be informative in strains where allele sizes are not known.
8
The use of genetic markers in poultry breeding
S. van der Beek
- 01 Jan 1996
TL;DR: The general discussion of this thesis addresses the status of the chicken linkage map, QTLs found in poultry, and discusses the usefulness of several applications of genetic markers in poultry breeding.
References
•Journal Article
The effects of conditioning on probands to correct for multiple ascertainment.
M Boehnke,D A Greenberg +1 more
TL;DR: In some cases, conditioning on probands actually resulted in greater parameter bias than no ascertainment correction at all, and these results hold for a variety of sibship-size distributions, several modes of inheritance, and a wide range of population prevalences of affected individuals.
28
Ascertainment in the sequential sampling of pedigrees.
TL;DR: In this article, the authors show that provided all observed families are included in the analysis, even those which appeared "uninteresting" or "sporadic" and were not sampled further, and provided a decision to continue sampling is made conditional on types observed up to that point, the correct likelihood for the mode of inheritance may be easily computed.