Journal Article10.1016/J.BPA.2015.09.006
Analgesia, sedation, and neuromuscular blockade during targeted temperature management after cardiac arrest
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TL;DR: The potential therapeutic goals for sedation, analgesia, and neuromuscular blockade during targeted temperature management; the adverse events associated with that treatment; data suggesting that TTM and organ dysfunction impair drug metabolism; and controversies and potential benefits of specific monitoring are reviewed.
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About: This article is published in Best Practice & Research Clinical Anaesthesiology. The article was published on 01 Dec 2015. The article focuses on the topics: Neuromuscular Blockade & Sedation.
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Citations
The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society.
Lori Kennedy Madden,Michelle Hill,Teresa May,Theresa Human,Mary Guanci,Judith Jacobi,Melissa V. Moreda,Neeraj Badjatia +7 more
TL;DR: This guideline is intended for neurocritical care clinicians who have chosen to use TTM in patient care; it is not meant to provide guidance regarding the clinical indications for TTM itself.
Neurological Pupil Index and Pupillary Light Reflex by Pupillometry Predict Outcome Early After Cardiac Arrest
Richard R. Riker,Mary Sawyer,Victoria Fischman,Teresa May,Christine Lord,Ashley Eldridge,David B. Seder +6 more
TL;DR: Very early after resuscitation from cardiac arrest, abnormal Neurological Pupil index and pupillary light reflex measurements by pupillometer are predictive of poor outcome, and are not usually associated with dilated pupils.
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Late awakening, prognostic factors and long-term outcome in out-of-hospital cardiac arrest - results of the prospective Norwegian Cardio-Respiratory Arrest Study (NORCAST).
Espen Rostrup Nakstad,Henrik Stær-Jensen,Henning Wimmer,Julia Henriksen,Lars Alteheld,Antje S. Reichenbach,Tomas Drægni,Jūratė Šaltytė-Benth,John Aage Wilson,Lars Etholm,Miriam Øijordsbakken,Jan Eritsland,Ingebjørg Seljeflot,Dag Jacobsen,Geir Øystein Andersen,Christofer Lundqvist,Kjetil Sunde +16 more
TL;DR: Most clinical parameters had too high FPRs for prognostication, except for absent PLR and SSEP-responses >72 h after sedation withdrawal, and increased NSE later than 24’h to >80 μg/L.
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Sedation depth and long-term mortality in mechanically ventilated critically ill adults.A prospective longitudinal multicentre cohort study
Mohd Shahnaz
- 01 Feb 2013
TL;DR: Irrespective of sedative choice, early deep sedation was independently associated with delayed extubation and higher mortality, and thus was a potentially modifiable risk in interventional trials.
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TL;DR: The rapid increase in the prevalence and disease burden of elevated BMI highlights the need for continued focus on surveillance of BMI and identification, implementation, and evaluation of evidence‐based interventions to address this problem.
Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
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TL;DR: This randomized, controlled trial compared the effects of moderate hypothermia and normothermia in patients who remained unconscious after resuscitation from out-of-hospital cardiac arrest to survive to hospital discharge and be discharged to home or to a rehabilitation facility.
Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest
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TL;DR: In patients who have been successfully resuscitated after cardiac arrest due to ventricular fibrillation, therapeutic mild hypothermia increased the rate of a favorable neurologic outcome and reduced mortality.
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Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit
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TL;DR: These guidelines provide a roadmap for developing integrated, evidence-based, and patient-centered protocols for preventing and treating pain, agitation, and delirium in critically ill patients.
Part 9: Post-Cardiac Arrest Care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Mary Ann Peberdy,Clifton W. Callaway,Robert W. Neumar,Romergryko G. Geocadin,Janice L. Zimmerman,Michael W. Donnino,Andrea Gabrielli,Scott M. Silvers,Arno Zaritsky,Raina M. Merchant,Terry L. Vanden Hoek,Steven L. Kronick +11 more
TL;DR: The goal of immediate post-cardiac arrest care is to optimize systemic perfusion, restore metabolic homeostasis, and support organ system function to increase the likelihood of intact neurological survival.
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