An update on memory reconsolidation updating

TL;DR: It is shown that reconsolidated memories imprint a more locally efficient network that is better at exchanging information, compared with memories that were retrained or untreated, and a method to elucidate the neural footprints associated with a relevant function of memory reconsolidation is reported.

TL;DR: A key role of the dlPFC, presumably in interaction with the hippocampus, in the updating of established memories is suggested, as shown by increased activity of the dorsolateral prefrontal cortex (dlPFC) specifically during the update of existing associations that was significantly stronger than when simple retrieval or new encoding was required.

TL;DR: The results indicate that OT did not block reconsolidation to prevent the return of threat memory but rather interacted with post-retrieval processes to facilitate next day extinction.

TL;DR: This study shows that rewarding and anxiolytic effects of caffeine during fear reactivation can change the emotional valence of fear memory and brings a new promising pharmacological approach based on drugs widely used such as caffeine to treat fear-related disorders.

TL;DR: A heated debate has been revitalized on whether memories become labile and must undergo some form of renewed consolidation every time they are activated, and on fundamental issues concerning the nature of the memory trace, its maturation, persistence, retrievability, and modifiability.

TL;DR: The findings indicate that the long-lasting trace of an experience is not completely fixed, consolidated, or coded at the time of the experience, and that any search for the engram or the basis of memory is not going to be successful.

TL;DR: The adaptive role of reconsolidation as a window of opportunity to rewrite emotional memories is demonstrated, and a non-invasive technique that can be used safely in humans to prevent the return of fear is suggested.

TL;DR: The temporal dynamics of memory reconsolidation are dependent on the strength and age of the memory, such that younger and weaker memories are more easily reconsolidated than older and stronger memories.