An update on memory reconsolidation updating
TL;DR: Progress on reconsolidation updating studies is reviewed, highlighting their translational exploitation and addressing recent challenges to the reconsolidations field.
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About: This article is published in Trends in Cognitive Sciences. The article was published on 01 Jul 2017. and is currently open access. The article focuses on the topics: Memory consolidation.
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Citations
Opening the reconsolidation window using the mind's eye: Extinction training during reconsolidation disrupts fear memory expression following mental imagery reactivation.
TL;DR: In this article, mental imagery rather than external stimulation was used to reactivate an aversive conditioned memory for the purposes of attenuating fear with subsequent extinction training, and no evidence of fear recovery on the first trial of re-extinction for the reminded, mentally imaged, CS+, whereas fear returned for the non-reminded CS+.
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Molecular and circuit mechanisms regulating cocaine memory.
TL;DR: This review will focus on the vast literature examining the mechanisms of cocaine Pavlovian associative memories with an emphasis on the molecular memory mechanisms and circuits involved in the consolidation, reconsolidation, and extinction of these memories.
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Behavioral, neurobiological, and neurochemical mechanisms of ethanol self-administration: A translational review.
TL;DR: Ethanol's interactions with a variety of neurotransmitter systems are discussed, summarizing findings from preclinical and translational studies to highlight recent progress in the field and summarize the behavioral changes induced by chronic ethanol self-administration.
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Emergence of a predictive model in the hippocampus
Adam M. P. Miller,Alexander D. Jacob,Adam I. Ramsaran,Mitchell L. de Snoo,Sheena A. Josselyn,Paul W. Frankland +5 more
TL;DR: In this paper , the hippocampal CA1 population activity is hypothesized to reflect predictive models that contain information about future events, but little is known about how memories are formed and updated.
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Acute but Not Permanent Effects of Propranolol on Fear Memory Expression in Humans.
TL;DR: The findings of this double-blind, placebo-controlled study fail to corroborate previous reports of propranolol-induced post-reactivation amnesia in humans, but do point to acute effects of proPRanolol administration on extinction performance.
References
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
TL;DR: It is shown that consolidated fear memories, when reactivated during retrieval, return to a labile state in which infusion of anisomycin shortly after memory reactivation produces amnesia on later tests, regardless of whether reactivation was performed 1 or 14 days after conditioning.
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The Neurobiology of Consolidations, Or, How Stable is the Engram?
TL;DR: A heated debate has been revitalized on whether memories become labile and must undergo some form of renewed consolidation every time they are activated, and on fundamental issues concerning the nature of the memory trace, its maturation, persistence, retrievability, and modifiability.
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Time-dependent processes in memory storage
TL;DR: The findings indicate that the long-lasting trace of an experience is not completely fixed, consolidated, or coded at the time of the experience, and that any search for the engram or the basis of memory is not going to be successful.
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Preventing the return of fear in humans using reconsolidation update mechanisms
Daniela Schiller,Marie H. Monfils,Marie H. Monfils,Candace M. Raio,David C. Johnson,Joseph E. LeDoux,Elizabeth A. Phelps,Elizabeth A. Phelps +7 more
TL;DR: The adaptive role of reconsolidation as a window of opportunity to rewrite emotional memories is demonstrated, and a non-invasive technique that can be used safely in humans to prevent the return of fear is suggested.
Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures
Akinobu Suzuki,Sheena A. Josselyn,Sheena A. Josselyn,Paul W. Frankland,Paul W. Frankland,Shoichi Masushige,Alcino J. Silva,Satoshi Kida +7 more
TL;DR: The temporal dynamics of memory reconsolidation are dependent on the strength and age of the memory, such that younger and weaker memories are more easily reconsolidated than older and stronger memories.
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