An Organogold Compound as Potential Antimicrobial Agent against Drug-Resistant Bacteria: Initial Mechanistic Insights
Parichita Chakraborty,Dorenda Oosterhuis,Riccardo Bonsignore,Angela Casini,Peter Olinga,Dirk-Jan Scheffers +5 more
TL;DR: In this article, the antibacterial activity of seven gold complexes of different families was evaluated in Bacillus subtilis and showed that cyclometalated Au(III) C^N complex showed activity against Gram-positive bacteria, including multi-drug resistant clinical strains.
read more
Abstract: The rise of antimicrobial resistance has necessitated novel strategies to efficiently combat pathogenic bacteria. Metal-based compounds have been proven as a possible alternative to classical organic drugs. Here, we have assessed the antibacterial activity of seven gold complexes of different families. One compound, a cyclometalated Au(III) C^N complex, showed activity against Gram-positive bacteria, including multi-drug resistant clinical strains. The mechanism of action of this compound was studied in Bacillus subtilis. Overall, the studies point towards a complex mode of antibacterial action, which does not include induction of oxidative stress or cell membrane damage. A number of genes related to metal transport and homeostasis were upregulated upon short treatment of the cells with gold compound. Toxicity tests conducted on precision-cut mouse tissue slices ex vivo revealed that the organogold compound is poorly toxic to mouse liver and kidney tissues, and may thus, be treated as an antibacterial drug candidate.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Metals to combat antimicrobial resistance
TL;DR: In this paper , a review summarizes recent developments in this growing field, focusing on advances in the development of metalloantibiotics, in particular, those for which the mechanism of action has been investigated.
Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications.
Randall T. Mertens,Sailajah Gukathasan,Adedamola S. Arojojoye,Chibuzor Olelewe,Samuel G. Awuah +4 more
TL;DR: A review of gold-based small molecules for infectious diseases, cancer, inflammation, and tools for chemical biology via gold-protein interactions is presented in this paper , which provides readers with an accessible overview of the utility, development, and mechanism of action of gold based small molecules to establish context and basis for the thriving resurgence of gold in medicine.
58
An Organogold Compound as Potential Antimicrobial Agent against Drug-Resistant Bacteria: Initial Mechanistic Insights
Parichita Chakraborty,Dorenda Oosterhuis,Riccardo Bonsignore,Angela Casini,Peter Olinga,Dirk-Jan Scheffers +5 more
TL;DR: In this article, the antibacterial activity of seven gold complexes of different families was evaluated in Bacillus subtilis and showed that cyclometalated Au(III) C^N complex showed activity against Gram-positive bacteria, including multi-drug resistant clinical strains.
Gold-Derived Molecules as New Antimicrobial Agents
TL;DR: This mini review revises the role of gold-derived molecules as antibacterial agents and concludes that gold complexes, with their broad-spectrum antimicrobial activities and unique modes of action, are particularly relevant among several families of derivatives that have been investigated.
Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action.
TL;DR: Recent advances in metal-based antibacterial agents are reviewed, including metal complexes, metal ions and catalytic metallodrugs, and how they can exploit their unique properties to tackle AMR are reviewed.
26
References
Gold complexes as antimicrobial agents: an overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure
TL;DR: Gold(I) and gold(III) complexes have been reported to be potential agents against parasites that cause amoebiasis, leishmaniasis and trypanosomiasis and a systematic summary of these results could contribute to the future design of new gold(I), gold( III) complexes as potential antimicrobial agents.
206
Cisplatin and Oxaliplatin: Our Current Understanding of Their Actions.
TL;DR: This chapter provides a broad overview of the current understanding of the mechanism of action of platinum antic cancer agents, providing a framework for improving the rational design of better Pt-based anticancer agents.
179
Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram‐Positive Directed Antibacterial Effects
Claudia Schmidt,Bianka Karge,Rainer Misgeld,Aram Prokop,Raimo Franke,Mark Brönstrup,Ingo Ott +6 more
TL;DR: Gold complexes with N-heterocyclic carbene (NHC) ligands represent a promising class of metallodrugs for the treatment of cancer or infectious diseases, and antibacterial screening of the gold complexes showed a particularly high activity against Gram-positive strains, reflecting their high dependence on an intact Trx/TrxR system.
165
Metal Complexes, an Untapped Source of Antibiotic Potential?
TL;DR: The encouraging work that has been done on antimicrobial metal complexes, mainly over the last decade, is highlighted and possible modes of action are discussed and issues that remain to be addressed are emphasized.
164
Gold in medicine: a review of its use in the West before 1900.
TL;DR: In this paper, the efficacy of gold compounds in the treatment of rheumatoid arthritis was confirmed, and they form an important, and sometimes colourful, part of the history of pharmacology and medicine.