An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii.
TL;DR: An overview of the current knowledge of the genus Acinetobacter is presented, with the emphasis on the clinically most important species, Acetobacter baumannii.
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Abstract: Since the 1970s, the spread of multidrug-resistant (MDR) Acinetobacter strains among critically ill, hospitalized patients, and subsequent epidemics, have become an increasing cause of concern. Reports of community-acquired Acinetobacter infections have also increased over the past decade. A recent manifestation of MDR Acinetobacter that has attracted public attention is its association with infections in severely injured soldiers. Here, we present an overview of the current knowledge of the genus Acinetobacter, with the emphasis on the clinically most important species, Acinetobacter baumannii.
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Citations
Clinical characteristics and outcomes of bacteremia due to different genomic species of Acinetobacter baumannii complex in patients with solid tumors
Mei-Chun Chiang,Shu-Chen Kuo,Shu-Chen Kuo,Su-Jung Chen,Su-Pen Yang,Yi Tzu Lee,Te-Li Chen,Te-Li Chen,Chang-Phone Fung,Chang-Phone Fung +9 more
TL;DR: Infection with A. baumannii and a high APACHE II score (≥21) might be associated with poor outcome in patients with solid tumors and ABC bacteremia.
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Characterisation and genome sequence of the lytic Acinetobacter baumannii bacteriophage vB_AbaS_Loki.
Dann Turner,Matthew E. Wand,Yves Briers,Yves Briers,Rob Lavigne,J. Mark Sutton,Darren M. Reynolds +6 more
TL;DR: Sequencing revealed that Loki encapsulates a 41,308 bp genome, encoding 51 predicted open reading frames, and is characterised by a narrow host range, among the 40 Acinetobacter isolates tested, productive infection was only observed for the propagating host, A. baumannii ATCC 17978.
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•Journal Article
Time dependent enhanced resistance against antibiotics & metal salts by planktonic & biofilm form of Acinetobacter haemolyticus MMC 8 clinical isolate
Sharvari Gaidhani,Aartee Vishnu Raskar,Sharmishtha Poddar,Shriya Gosavi,Praveen K. Sahu,Karishma Pardesi,Shobhana V. Bhide,Balu Ananada Chopade +7 more
TL;DR: The results indicate that biofilm formation causes enhanced resistance against antibiotics and metal salts in otherwise susceptible planktonic A. haemolyticus MMC 8.
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Scarless Removal of Large Resistance Island AbaR Results in Antibiotic Susceptibility and Increased Natural Transformability in Acinetobacter baumannii.
Anne-Sophie Godeux,Anne-Sophie Godeux,Elin Svedholm,Agnese Lupo,Marisa Haenni,Samuel Venner,Maria-Halima Laaberki,Maria-Halima Laaberki,Xavier Charpentier +8 more
TL;DR: A versatile scarless genome editing strategy is devised that effectively inactivates comM and that the restored comM is functional and provides insight into the functional consequences of AbaR acquisition.
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Potent and rapid bactericidal action of alyteserin-1c and its [E4K] analog against multidrug-resistant strains of Acinetobacter baumannii.
TL;DR: Synthetic alyteserin-1c displayed potent activity against clinical isolates of MDRAB while displaying low hemolytic activity against human erythrocytes and retained antimicrobial activity but showed dramatically increased hemolyic activities (>40- and >13-fold, respectively).
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References
Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features.
TL;DR: The taxonomic status of Acinetobacter spp.
Global Challenge of Multidrug-Resistant Acinetobacter baumannii
Federico Perez,Andrea M. Hujer,Kristine M. Hujer,Brooke K. Decker,Philip N. Rather,Robert A. Bonomo,Robert A. Bonomo +6 more
TL;DR: This review summarizes the worldwide emergence of antibiotic-resistant A. baumannii as a nosocomial pathogen and focuses on its mechanisms of resistance against selected antibiotics.
1.2K
Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology
Laurent Poirel,Patrice Nordmann +1 more
TL;DR: In addition to beta-lactamases, carbapenem resistance in A. baumannii may also result from porin or penicillin-binding protein modifications, and several porins, including the 33-kDa CarO protein, that constitute a pore channel for influx ofcarbapenems, might be involved in carbapanem resistance.
1K
Comparative Genomics of Multidrug Resistance in Acinetobacter baumannii
Pierre-Edouard Fournier,David Vallenet,Valérie Barbe,Stéphane Audic,Hiroyuki Ogata,Laurent Poirel,Hervé Richet,Catherine Robert,Sophie Mangenot,Chantal Abergel,Patrice Nordmann,Jean Weissenbach,Didier Raoult,Jean-Michel Claverie +13 more
TL;DR: In this paper, the authors used a comparative genomic approach to identify the complete repertoire of resistance genes exhibited by the multidrug-resistant A. baumannii strain AYE, which is epidemic in France, as well as investigate the mechanisms of their acquisition by comparison with the fully susceptible A. bayannii species SDF, associated with human body lice.
The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii
Jane F. Turton,M. Elaina Ward,Neil Woodford,Mary E. Kaufmann,Rachel Pike,David M. Livermore,Tyrone L. Pitt +6 more
TL;DR: Results suggest that ISAba1 is providing the promoter for blaOXA-51-like and, probably, for blasOxA-23-like, which are likely to be the next generation of Acinetobacter baumannii isolates.
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