An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii.
TL;DR: An overview of the current knowledge of the genus Acinetobacter is presented, with the emphasis on the clinically most important species, Acetobacter baumannii.
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Abstract: Since the 1970s, the spread of multidrug-resistant (MDR) Acinetobacter strains among critically ill, hospitalized patients, and subsequent epidemics, have become an increasing cause of concern. Reports of community-acquired Acinetobacter infections have also increased over the past decade. A recent manifestation of MDR Acinetobacter that has attracted public attention is its association with infections in severely injured soldiers. Here, we present an overview of the current knowledge of the genus Acinetobacter, with the emphasis on the clinically most important species, Acinetobacter baumannii.
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Use of the accessory genome for characterization and typing of Acinetobacter baumannii.
TL;DR: VNTR data is supported in describing distinct populations of highly similar isolates of A. baumannii among a set of clinical isolates that included multiple representatives of a number of pulsed-field gel electrophoresis (PFGE)-defined types.
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Molecular Detection of Class-D OXA Carbapenemase Genes in Biofilm and Non-Biofilm Forming Clinical Isolates of Acinetobacter baumannii
TL;DR: The prevalence of molecular class-D OXA carbapenemase in biofilm and non-biofilm forming strains of MDR-AB was determined particularly with indiscriminate use of imipenem, complicated treatment of the patients infected with these bacteria in the hospitals understudy.
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Clinical Carbapenem-Resistant Acinetobacter baylyi Strain Coharboring blaSIM-1 and blaOXA-23 from China
TL;DR: Two genes, blaSIM-1 and blaOXA-23, were codetected in clinical carbapenem-resistant Acinetobacter baylyi strain NB09A30 and the genetic structure of blaOxA- 23 in NB 09A30 was different from that in the prevalent AcinetOBacter baumannii of clonal complex 92 from the same hospital.
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Oligonucleotide Array-Based Identification of Species in the Acinetobacter calcoaceticus-A. baumannii Complex in Isolates from Blood Cultures and Antimicrobial Susceptibility Testing of the Isolates
Wen Chien Ko,Nan Yao Lee,Siou Ching Su,Lenie Dijkshoorn,Mario Vaneechoutte,Li Rong Wang,Jin Jou Yan,Tsung Chain Chang +7 more
TL;DR: Significant variations in antimicrobial susceptibility among different species in the A. calcoaceticus-A.
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References
Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features.
TL;DR: The taxonomic status of Acinetobacter spp.
Global Challenge of Multidrug-Resistant Acinetobacter baumannii
Federico Perez,Andrea M. Hujer,Kristine M. Hujer,Brooke K. Decker,Philip N. Rather,Robert A. Bonomo,Robert A. Bonomo +6 more
TL;DR: This review summarizes the worldwide emergence of antibiotic-resistant A. baumannii as a nosocomial pathogen and focuses on its mechanisms of resistance against selected antibiotics.
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Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology
Laurent Poirel,Patrice Nordmann +1 more
TL;DR: In addition to beta-lactamases, carbapenem resistance in A. baumannii may also result from porin or penicillin-binding protein modifications, and several porins, including the 33-kDa CarO protein, that constitute a pore channel for influx ofcarbapenems, might be involved in carbapanem resistance.
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Comparative Genomics of Multidrug Resistance in Acinetobacter baumannii
Pierre-Edouard Fournier,David Vallenet,Valérie Barbe,Stéphane Audic,Hiroyuki Ogata,Laurent Poirel,Hervé Richet,Catherine Robert,Sophie Mangenot,Chantal Abergel,Patrice Nordmann,Jean Weissenbach,Didier Raoult,Jean-Michel Claverie +13 more
TL;DR: In this paper, the authors used a comparative genomic approach to identify the complete repertoire of resistance genes exhibited by the multidrug-resistant A. baumannii strain AYE, which is epidemic in France, as well as investigate the mechanisms of their acquisition by comparison with the fully susceptible A. bayannii species SDF, associated with human body lice.
The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii
Jane F. Turton,M. Elaina Ward,Neil Woodford,Mary E. Kaufmann,Rachel Pike,David M. Livermore,Tyrone L. Pitt +6 more
TL;DR: Results suggest that ISAba1 is providing the promoter for blaOXA-51-like and, probably, for blasOxA-23-like, which are likely to be the next generation of Acinetobacter baumannii isolates.
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