An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii.
TL;DR: An overview of the current knowledge of the genus Acinetobacter is presented, with the emphasis on the clinically most important species, Acetobacter baumannii.
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Abstract: Since the 1970s, the spread of multidrug-resistant (MDR) Acinetobacter strains among critically ill, hospitalized patients, and subsequent epidemics, have become an increasing cause of concern. Reports of community-acquired Acinetobacter infections have also increased over the past decade. A recent manifestation of MDR Acinetobacter that has attracted public attention is its association with infections in severely injured soldiers. Here, we present an overview of the current knowledge of the genus Acinetobacter, with the emphasis on the clinically most important species, Acinetobacter baumannii.
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Acinetobacter infection--an emerging threat to human health.
TL;DR: Several epidemic clonal lineages of A. baumannii seem to have a selective advantage over non‐epidemic strains, and could be related to the potential of these organisms to achieve very dynamic reorganization and rapid evolution of their genome, including the acquisition and expression of additional antibiotic resistance determinants, under fluctuating environmental and selective conditions.
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Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.
Jonathan M. Stokes,Craig R. MacNair,Bushra Ilyas,Shawn French,Jean-Philippe Côté,Catrien Bouwman,Maya A. Farha,Arthur O. Sieron,Chris Whitfield,Brian K. Coombes,Eric D. Brown +10 more
TL;DR: An unconventional screening platform designed to enrich for non-lethal, outer-membrane-active compounds with potential as adjuvants for conventional antibiotics is described, identifying the antiprotozoal drug pentamidine6 as an effective perturbant of the Gram-negative outer membrane through its interaction with lipopolysaccharide.
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Characterization of a two-component regulatory system from Acinetobacter baumannii that controls biofilm formation and cellular morphology
TL;DR: Results indicate that BfmR is part of a two-component regulatory system that plays an important role in the morphology of A. baumannii 19606 cells and their ability to form biofilms on abiotic surfaces.
296
Biodegradation of levofloxacin by an acclimated freshwater microalga, Chlorella vulgaris
TL;DR: These results demonstrated that the enhanced removal of LEV by salinity was mainly through bioaccumulation and subsequent intracellular biodegradation by C. vulgaris cells.
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Global Survey of Antibiotic Resistance Genes in Air
Jing Li,Junji Cao,Yong-Guan Zhu,Qing-Lin Chen,Fangxia Shen,Yan Wu,Siyu Xu,Hanqing Fan,Guillaume Da,Ru-Jin Huang,Jing Wang,Jing Wang,Alma Lorelei de Jesus,Lidia Morawska,Chak K. Chan,Jordan Peccia,Maosheng Yao +16 more
TL;DR: In this paper, relative abundances (as a fraction, normalized by 16S rRNA gene) of 30 ARG subtypes resistant to seven common classes of antibiotics, which are quinolones, β-lactams, macrolides, tetracyclines, sulfonamides, aminoglycosides, and vancomycins, were profiled.
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References
Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features.
TL;DR: The taxonomic status of Acinetobacter spp.
Global Challenge of Multidrug-Resistant Acinetobacter baumannii
Federico Perez,Andrea M. Hujer,Kristine M. Hujer,Brooke K. Decker,Philip N. Rather,Robert A. Bonomo,Robert A. Bonomo +6 more
TL;DR: This review summarizes the worldwide emergence of antibiotic-resistant A. baumannii as a nosocomial pathogen and focuses on its mechanisms of resistance against selected antibiotics.
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Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology
Laurent Poirel,Patrice Nordmann +1 more
TL;DR: In addition to beta-lactamases, carbapenem resistance in A. baumannii may also result from porin or penicillin-binding protein modifications, and several porins, including the 33-kDa CarO protein, that constitute a pore channel for influx ofcarbapenems, might be involved in carbapanem resistance.
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Comparative Genomics of Multidrug Resistance in Acinetobacter baumannii
Pierre-Edouard Fournier,David Vallenet,Valérie Barbe,Stéphane Audic,Hiroyuki Ogata,Laurent Poirel,Hervé Richet,Catherine Robert,Sophie Mangenot,Chantal Abergel,Patrice Nordmann,Jean Weissenbach,Didier Raoult,Jean-Michel Claverie +13 more
TL;DR: In this paper, the authors used a comparative genomic approach to identify the complete repertoire of resistance genes exhibited by the multidrug-resistant A. baumannii strain AYE, which is epidemic in France, as well as investigate the mechanisms of their acquisition by comparison with the fully susceptible A. bayannii species SDF, associated with human body lice.
The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii
Jane F. Turton,M. Elaina Ward,Neil Woodford,Mary E. Kaufmann,Rachel Pike,David M. Livermore,Tyrone L. Pitt +6 more
TL;DR: Results suggest that ISAba1 is providing the promoter for blaOXA-51-like and, probably, for blasOxA-23-like, which are likely to be the next generation of Acinetobacter baumannii isolates.
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