An Expanded View of Complex Traits: From Polygenic to Omnigenic

doi:10.1016/J.CELL.2017.05.038

Open AccessJournal Article10.1016/J.CELL.2017.05.038

An Expanded View of Complex Traits: From Polygenic to Omnigenic

Evan A. Boyle, +3 more

- 15 Jun 2017

- Cell

- Vol. 169, Iss: 7, pp 1177-1186

2.8K

TL;DR: It is proposed that gene regulatory networks are sufficiently interconnected such that all genes expressed in disease-relevant cells are liable to affect the functions of core disease-related genes and that most heritability can be explained by effects on genes outside core pathways.

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