An Expanded View of Complex Traits: From Polygenic to Omnigenic

TL;DR: This review article will summarize these recent GWAS of CKD and kidney function-related traits, explain approaches for downstream characterization of associated genetic loci and the value of such computational follow-up analyses, and discuss related challenges along with potential solutions to ultimately enable improved treatment and prevention of kidney diseases through genetics.

TL;DR: It is envisioned that population-scale NGS with paired electronic health records (EHRs) will become a routine measure in the drug development process for the identification of novel drug targets, and that genetically stratified clinical trials could be widely adopted to improve power in precision-medicine-guided drug development.

TL;DR: It is observed that schizophrenia appears to be on a developmental continuum with other behavioral disorders with onset in childhood, including autism, intellectual disability and epilepsy, arising perhaps from overlapping biological risk factors that may each have distinct covariates.

TL;DR: This work is the first attempt to assess the importance of co-expression network connectivity in phenotype prediction and found that cores were more differentiated between populations than peripherals while being less variable, suggesting that they have been constrained through potentially divergent selection.

TL;DR: This work aims to understand how an enormous network of interacting dynamical systems — be they neurons, power stations or lasers — will behave collectively, given their individual dynamics and coupling architecture.

TL;DR: This paper examined potential sources of missing heritability and proposed research strategies, including and extending beyond current genome-wide association approaches, to illuminate the genetics of complex diseases and enhance its potential to enable effective disease prevention or treatment.

TL;DR: Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.

TL;DR: It is shown that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease.