An Early Cancer Diagnosis Platform based on Micro-magnetic SensorArray Demonstrates Ultra-high Sensitivity
TL;DR: The patterned GMR multiple-bio-sensor array, has demonstrated real-time measurements of carcinoembryonic antigen (CEA) protein concentrations down to femtomole level in a variety of clinically relevant media with a linear dynamic range of over five orders of magnitude.
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Abstract: In this paper a highly sensitive detection methodology for obtaining the concentration of protein tumor markers via the selective incorporation of super paramagnetic iron oxide nanoparticles (MNP) onto an antigen is reported The tumor marker concentration is measured with a nano-oxide layer inserted giant magneto-resistive (GMR) sensor that determines the attenuation of an external magnetic field that is induced by the MNP The 15 nm MNPs, used herein, exhibit a super paramagnetic behavior with saturation magnetization of 36 emu/g The output voltage signal of the Specular GMR sensor is 500 μV/Oe The patterned GMR multiple-bio-sensor array, has demonstrated real-time measurements of carcinoembryonic antigen (CEA) protein concentrations down to femtomole level (10-15 mole) in a variety of clinically relevant media with a linear dynamic range of over five orders of magnitude The sensitivity of the GMR bio-array platform is 1000 times higher than conventional enzyme-linked immunosorbent assay (ELISA) technique The arrays of magnetoresistive sensors offer great promise in applications for early cancer diagnosis
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Record-Low-Threshold Lasers Based on Atomically Smooth Triangular Nanoplatelet Perovskite
Abstract: Single‐crystalline perovskites are ideal candidates for lasing and other optoelectronic applications. Although significant efforts have been made to grow both bulk single‐crystalline perovskites in liquid solution, their dimensions are still too large to make nanoscale whispering‐gallery‐mode (WGM) resonator based lasers that possess high quality (Q) factor and small volume. Besides, most reported perovskite resonators do not possess atomically smooth surfaces and facets, which limits the Q and thereby increases the lasing threshold. Here, atomically smooth triangular PbI2 templates are fabricated on a mica substrate by the vapor phase deposition method and are converted to atomically smooth perovskites which have regular and unwrinkled facets with average surface roughness less than 2 nm. By using a CH3NH3PbI3 nanoplatelet with a side length of 27 µm and thickness of 80 nm, room temperature WGM lasing with a Q up to 2600 is demonstrated, the highest reported for hybrid organic–inorganic perovskite nanoplatelets. In addition, the volume of the WGM mode is reduced significantly in comparison with the prior reports. The realized high‐quality triangular CH3NH3PbI3 perovskite nanoplatelets with high Q factor and small volume are expected to perform as ideal cavities for long pulse durations lasers and would find potential applications in integrated optoelectronic devices.
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Magnetic nanostructures for emerging biomedical applications
L. Peixoto,Ricardo Magalhães,David Navas,David Navas,S. Moraes,C. Redondo,Rafael Morales,Rafael Morales,João P. Araújo,Célia T. Sousa +9 more
TL;DR: In this paper, three different types of magnetic nanostructures, disks in the vortex state, synthetic antiferromagnetic particles and nanowires, are discussed, by explaining their interesting properties and how they behave under an applied external field.
66
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