An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest.

TL;DR: Study of resting-state oscillatory connectivity in healthy young humans genotyped for APOE-ɛ4 suggests that this is present decades before the onset of AD symptomology and supports theories of initial hyperconnectivity driving eventual profound disconnection in AD.

TL;DR: It is demonstrated that gyrification changes are related to connectivity, which supports the idea that an imbalance between short- and long-range white matter tracts not only impairs the integration of information from multiple neural systems, but also alters the shape of the brain early on in autism.

TL;DR: Associations between white matter volume, IIV, and ex-Gaussian RT distribution parameters in cognitively normal aging and early-stage AD support a role of white matter integrity in IIV and distributional skewing, and are consistent with the hypothesis thatIIV and RT distributional Skewing are sensitive to breakdowns in executive control processes in normal and pathological aging.

TL;DR: Differences in cognitive performance over time were investigated between neuroimaging biomarker groups for beta-amyloid and tau in initially cognitively unimpaired persons and the combination of pathologic beta-amide and t Tau was detrimental to cognitive decline in preclinical AD during late middle-age.

TL;DR: An anatomical parcellation of the spatially normalized single-subject high-resolution T1 volume provided by the Montreal Neurological Institute was performed and it is believed that this tool is an improvement for the macroscopical labeling of activated area compared to labeling assessed using the Talairach atlas brain.

TL;DR: A set of automated procedures for obtaining accurate reconstructions of the cortical surface are described, which have been applied to data from more than 100 subjects, requiring little or no manual intervention.

TL;DR: In this article, the authors propose three basic concepts: devising the items, selecting the items and selecting the responses, from items to scales, reliability and validity of the responses.