AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network.

TL;DR: An overview of potential novel antiarrhythmic approaches based on the underlying mechanisms of AF is provided, focusing both on the development of novelAntiarrhythmmic agents and on the possibility of repurposing already marketed drugs.

TL;DR: Hyperoside, delivered intravitreally, alleviated photoreceptor cell senescence and ameliorated the functional and morphological degeneration of the retina in vivo and in vitro, suggesting that visual function might be protected using anti‐aging treatment.

TL;DR: A synthetic Lipoxin A4 analogue, CYNC-2, modulates the AMPK/NLRP3 pathway to mitigate radiation-induced lung inflammation by suppressing pro-inflammatory cytokines and preserving cellular viability in a murine model and human lung cell lines.

TL;DR: Hub genes such as FOS and SIRT1 were regulated by SP1 and BRCA1, respectively, during HSC aging, and FOS and SIRT1 may be potential therapeutic targets for age-related hematopoietic dysfunction.

TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.

TL;DR: It is reported that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age.

TL;DR: Finding that mutations in the gene daf-2 can cause fertile, active, adult Caenorhabditis elegans hermaphrodites to live more than twice as long as wild type raises the possibility that the longevity of the dauer is not simply a consequence of its arrested growth, but instead results from a regulated lifespan extension mechanism that can be uncoupled from other aspects of dauer formation.

TL;DR: Autophagy is a cell biological process that is a central component of the integrated stress response and can be integrated with other cellular stress responses through parallel stimulation of autophagy and other stress responses by specific stress stimuli.