Journal Article10.1162/JOCN.1990.2.3.246
Amnesia due to lesions confined to the hippocampus: A clinical-pathologic study
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TL;DR: A 65-year-old man who suffered a burst of severe, repetitive generalized seizures (status epilepticus) was left with a profound impairment of memory, which remained unchanged for the subsequent 30 months of his life, fully documented.
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Abstract: Reported here is the case of a 65-year-old man who suffered a burst of severe, repetitive generalized seizures (status epilepticus). On recovery of consciousness he was left with a profound impairment of memory, which remained unchanged for the subsequent 30 months of his life. During this period the cognitive defect was fully documented. Careful neuropathologic examination disclosed the presence of remarkably discrete lesions, confined to the hippocampus on each side. Because of the rarity of well-documented instances of this type and their importance in the study of memory function, we are reporting our case in some detail.
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References
The medial temporal lobe memory system
TL;DR: The medial temporal lobe memory system is needed to bind together the distributed storage sites in neocortex that represent a whole memory, but the role of this system is only temporary, as time passes after learning, memory stored in neoc cortex gradually becomes independent of medialporal lobe structures.
Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus
TL;DR: This is the first reported case of amnesia following a lesion limited to the hippocampus in which extensive neuropsychological and neuropathological analyses have been carried out.
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The entorhinal cortex of the monkey: II. Cortical afferents
TL;DR: Whereas there is little available physiological information concerning many of the cortical regions that project to the entorhinal cortex, on anatomical grounds they may be generally characterized as poly sensory associational regions, this work has carried out a systematic analysis of these connections by placing small injections of the retrograde tracer wheat germ agglutinin conjugated to horseradish peroxidase into each of the fields of theEntorhinals monkey.
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Lesions of Perirhinal and Parahippocampal Cortex That Spare the Amygdala and Hippocampal Formation Produce Severe Memory Impairment
TL;DR: It is suggested that the severe memory impairment in monkeys and humans associated with bilateral medial temporal lesions results from damage to the hippocampal formation and adjacent, anatomically related cortex, not from conjoint hippocampus-amygdala damage.
Lesions of the amygdala that spare adjacent cortical regions do not impair memory or exacerbate the impairment following lesions of the hippocampal formation
TL;DR: For example, this paper found that lesions of the amygdaloid complex did not impair performance on 4 different memory tasks, nor did they exacerbate the memory impairment that followed hippocampal formation lesions alone.
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