Journal Article10.1093/BRAIN/87.2.307
Alzheimer’s disease —an electron microscopical study
422
About: This article is published in Brain. The article was published on 01 Jun 1964. The article focuses on the topics: Amyloid & Cerebral cortex.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets.
TL;DR: To prevent the clinical progression of neurodegeneration, a combination strategy is suggested to target both senile plaques with immunization and neurofibrillary tangles with drugs to prevent the synthesis and phosphorylation of tau.
52
Cortical cholinergic denervation elicits vascular A beta deposition.
Alex E. Roher,Yu Min Kuo,Pamela E. Potter,Mark R. Emmerling,Robert A. Durham,Douglas G. Walker,Lucia I. Sue,William G. Honer,Thomas G. Beach +8 more
TL;DR: The selective removal of the rabbit nbm and Aβ accumulation may serve as an important nontransgenic, and more physiological, model for the testing of pharmacological and immunological agents designed to control the deposition and the deleterious effects of Aβ in AD.
51
Senile dementia and Alzheimer's disease: a current view.
TL;DR: A significant “heterochromatization” was found to occur in chromatin from brains of patients who had died with this disease, suggesting that a major alteration in Chromatin structure may be related to the etiology of this condition.
50
Neurofibrillary pathology: current status and research perspectives.
TL;DR: On the basis of the morphological and biochemical evidence, several approaches to the experimental study of neurofibrillary pathology are proposed and the emphasis on the normal neurofibillary structures being single forms of pleomorphic proteins is placed.
50