Journal Article10.1016/J.ECHO.2006.01.009
Alterations in left ventricular structure and function in type-1 diabetics: a focus on left atrial contribution to function.
Linda R. Peterson,Alan D. Waggoner,Lisa de las Fuentes,Kenneth B. Schechtman,Janet B. McGill,Robert J. Gropler,Victor G. Davila-Roman +6 more
TL;DR: Despite increased relative wall thickness, LV systolic function is increased and early diastolic filling is normal in T1DM subjects; however, they possess changes in LA transport function suggesting increased reliance on LA contribution to LV filling.
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Abstract: This study was designed to determine the effects of type 1 diabetes mellitus (T1DM) on left ventricular (LV) and particularly left atrial (LA) structure and function. We evaluated 88 non-obese subjects: 44 with T1DM, 44 age- and gender-matched normal controls (age 39 ± 11 years). LV and LA structure and function were quantified using two-dimensional echocardiography, pulse-wave Doppler, and tissue Doppler imaging, including early and late diastolic myocardial velocities (Em global and Am global, respectively). The T1DM subjects averaged higher heart rate, relative wall thickness, and ejection fraction, and lower indexed end-systolic volume than normal controls ( P P P = .01, and P P P P P P P P P
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Citations
Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation.
TL;DR: The mechanisms involved in LA remodeling are described and the existing and potential therapeutic options for its reversal are highlighted, and implications for AF development are highlighted.
495
The CHADS2 score predicts ischemic stroke in the absence of atrial fibrillation among subjects with coronary heart disease: data from the Heart and Soul Study.
Christine C. Welles,Mary A. Whooley,Mary A. Whooley,Beeya Na,Peter Ganz,Peter Ganz,Nelson B. Schiller,Mintu P. Turakhia,Mintu P. Turakhia +8 more
TL;DR: The CHADS(2) score predicts ischemic stroke/TIA in subjects with stable CHD and no baseline AF, a population known to derive benefit from stroke prevention therapies.
103
Atrial fibrillation and CHADS2 risk factors are associated with highly sensitive C-reactive protein incrementally and independently.
Mark A. Crandall,M.P.H. Benjamin D. Horne Ph.D.,M.P.H. Benjamin D. Horne Ph.D.,John D. Day,Jeffrey L. Anderson,Jeffrey L. Anderson,Joseph B. Muhlestein,Joseph B. Muhlestein,Brian G. Crandall,J. Peter Weiss,Donald L. Lappe,T. Jared Bunch +11 more
TL;DR: Inflammation has been shown to have a direct role in the initiation, maintenance, and recurrence of atrial fibrillation although the underlying mechanisms are unknown.
49
Tissue Doppler imaging must be performed to detect early left ventricular dysfunction in patients with type 1 diabetes mellitus.
Kamile Gul,Aksuyek Savas Celebi,Fehmi Kaçmaz,Ozlem Celebi Ozcan,Ihsan Ustun,Dilek Berker,Yusuf Aydin,Tuncay Delibasi,Serdar Güler,Ayse Ozden Barazi +9 more
TL;DR: TDI is a more accurate and powerful method than PW or M-mode in determination of early cardiac involvement related to type 1 DM even in the subclinical phase as well as hereditary cardiomyopathies.
Myocardial metabolism and cardiac performance in obesity and insulin resistance.
Stacy Banerjee,Linda R. Peterson +1 more
TL;DR: Understanding of mechanisms by which this triad may cause cardiac dysfunction will aid in the development of novel therapies, including metabolic manipulations that could prevent and treat cardiac dysfunction in patients with obesity, insulin resistance, and diabetes.
44
References
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