Aloe vera, wheat germ oil, tea tree extract and honey-based emollient cream in the management of atopic dermatitis: a post-hoc analysis

TL;DR: The aloe vera, wheat germ oil, tea tree extract, honey enriched emollient formulation was efficacious and well tolerable in study participants in providing moisturizing, antimicrobial, and anti-inflammatory effects making it a preferred complementary therapy for managing atopic dermatitis following the short course therapy with TCS.

Abstract: Background: Atopic dermatitis is a chronic skin condition characterized by dry, itchy and inflamed skin. This study evaluated the complementary benefits efficacy and tolerability of emollient c containing Aloe vera, Wheat germ oil, tea tree extract, and honey in patients with dry skin conditions. Methods: Cross-sectional analysis for clinical cases with dry skin receiving moisturizing cream formulation was undertaken at 156 centres. 286 case records of atopic dermatitis receiving standard of care as cleansers, Topical corticosteroids, moisturizers were further analysed for improvement in skin dryness and itchiness. Results: Regular use of Emollient formulation containing aloe vera, wheat germ oil, tea tree extract, honey was further analysed along with safety assessment over 8 weeks of observation period. The mean age of the study participants was 36.58 years. There was significant change in VAS score for dryness (p-value< 0.01), itch (p-value <0.01) with Patient Global Assessed rating as good (64.23%) for effectiveness and ease of application. Mild stinging, mild burning and irritation was experienced by 5 (1.75%) patients.  Conclusions: The aloe vera, wheat germ oil, tea tree extract, honey enriched emollient formulation was efficacious and well tolerable in study participants in providing moisturizing, antimicrobial, and anti-inflammatory effects making it a preferred complementary therapy for managing atopic dermatitis following the short course therapy with TCS as a pertinent clinical strategy to avoid the atopic flares in such cases.