1. What are the contributions mentioned in the paper "Allogeneic hematopoietic stem-cell transplantation for patients 50 years or older with myelodysplastic syndromes or secondary acute myeloid leukemia" ?
This study was performed to examine the characteristics of transplant activity for patients with myelodysplastic syndromes ( MDS ) older than 50 years within the European Group for Blood and Marrow Transplantation, and to evaluate the factors predicting outcome within this group of patients.. The authors performed a retrospective multicenter analysis of 1,333 MDS patients age 50 years or older who received transplantation within the EBMT since 1998.. Conclusion Allogeneic hematopoietic stem-cell transplantation remains a potential curative therapeutic option for many older patients with MDS.
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2. What future works have the authors mentioned in the paper "Allogeneic hematopoietic stem-cell transplantation for patients 50 years or older with myelodysplastic syndromes or secondary acute myeloid leukemia" ?
Assessment scores such as the Charlson comorbidity score, or more recently, the specifically developed hematopoietic cell transplantation comorbidity index may help to improve patient selection,17-19 and comorbidity indices should be incorporated as part of transplant registry data collection forms for future studies.. The observation that patients receiving SMC have a lower relapse incidence when compared with patients receiving RIC in their cohort supports existing evidence suggesting that the dose intensity of the conditioning regimen has an important influence on the posttransplant remission rates.. 12 However, recent data from Scott et al22 on 150 patients with MDS/sAML receiving RIC or SMC regimens demonstrated that the overall and progression-free survival rates were similar for patients with chemotherapy-induced remissions irrespective of conditioning intensity, suggesting that graft versus leukemia effects may be more important in preventing progression in patients in chemotherapy-induced remissions at the time of transplantation.. Indeed, there is evidence to suggest that in selected older patients, an intensification of the reduce intensity conditioning regimens may be effective at treating patients with active disease at time of transplantation.
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3. What tests were used for differences in medians?
When groups were compared according to continuous covariates, the Mann-Whitney U test or Kruskal-Wallis one-way analysis of variance on ranks test were used for differences in medians.
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4. What was the major independent variable associated with an inferior 4-year OS?
Advanced disease stage at transplantation (HR, 1.55; 95% CI, 1.32 to 1.83; P .01) was the major independent variable associated with an inferior 4-year OS.
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