Aging and replicative senescence have related effects on human stem and progenitor cells.
Wolfgang Wagner,Wolfgang Wagner,Simone Bork,Patrick Horn,Damir Krunic,Thomas Walenda,Anke Diehlmann,Vladimir Benes,Jonathon Blake,Franz Xaver Huber,Volker Eckstein,Petra Boukamp,Anthony D. Ho +12 more
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Citations
Metformin alleviates aging-associated cellular senescence of human adipose stem cells and derived adipocytes
Matthieu Mantecon,Laura Pelletier,Jennifer Gorwood,Martine Auclair,Michael Atlan,Bruno Fève,Jacqueline Capeau,Claire Lagathu,Véronique Béréziat +8 more
TL;DR: It is shown that targeting senescent ASCs from aged women with metformin may alleviate age-related dysfunction, insulin resistance, and impaired adipogenesis.
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Dietary Polyphenols for Active and Healthy Ageing
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TL;DR: This RA-based method provides a protocol for generating an unlimited number of hPSC-derived MSCs that could be useful for cell therapy, drug screening, and disease modeling applications.
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Assessment of Colorectal Cancer Risk Factors through the Application of Network-Based Approaches in a Racially Diverse Cohort of Colon Organoid Stem Cells
TL;DR: In this article , the authors performed RNA sequencing of stem-cell-enriched organoids derived from the healthy colons of seven European Americans and eight African Americans, and performed weighted gene co-expression network analysis following RNA sequencing.
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Mesenchymal stem cells for repair of the peripheral and central nervous system
Maria Brohlin
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TL;DR: This thesis investigates whether adult huma stem cells provide neuroprotection after transplantation into the injured nervous system after bone marrow-derived mesenchymal stem cells (MSC) have been shown to provide neuro protection after transplanting into thejured nervous system.
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Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
TL;DR: Three methods of performing normalization at the probe intensity level are presented: a one number scaling based algorithm and a method that uses a non-linear normalizing relation by comparing the variability and bias of an expression measure and the simplest and quickest complete data method is found to perform favorably.
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The serial cultivation of human diploid cell strains.
Leonard Hayflick,P.S. Moorhead +1 more
TL;DR: A consideration of the cause of the eventual degeneration of these strains leads to the hypothesis that non-cumulative external factors are excluded and that the phenomenon is attributable to intrinsic factors which are expressed as senescence at the cellular level.
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The limited in vitro lifetime of human diploid cell strains
TL;DR: The survival curves obtained with human diploid cell strains are comparable to “multiple-hit” or “ multiple-target” curves obtain with other biological systems where an initial threshold dose is required before an exponential form of the curve is established.
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