Aging and replicative senescence have related effects on human stem and progenitor cells.
Wolfgang Wagner,Wolfgang Wagner,Simone Bork,Patrick Horn,Damir Krunic,Thomas Walenda,Anke Diehlmann,Vladimir Benes,Jonathon Blake,Franz Xaver Huber,Volker Eckstein,Petra Boukamp,Anthony D. Ho +12 more
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Stem cell-based tissue engineering approaches for musculoskeletal regeneration.
TL;DR: Current developments in tissue engineering are reviewed, focusing on several stem cell sources, induction factors including growth factors, oxygen tension, biomaterials, and mechanical stimulation, and the internal and external regulatory mechanisms that govern proliferation and differentiation.
65
Age-related changes in mesenchymal stem cells identified using a multi-omics approach.
Mandy J. Peffers,John A. Collins,Yongxiang Fang,Katarzyna Goljanek-Whysall,Michael D. Rushton,John Loughlin,Carole J. Proctor,Peter D. Clegg +7 more
TL;DR: An altered phenotype in MSC ageing at a number of levels implicated roles for inflamm-ageing and mitochondrial ageing and represents novel insights into the ageing process, with implications for stem cell therapies in older patients.
Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular-based therapy
Paola Cipriani,P. Di Benedetto,V. Liakouli,B. Del Papa,M. Di Padova,M Di Ianni,Alessandra Marrelli,Edoardo Alesse,Roberto Giacomelli +8 more
TL;DR: Increased activation of the IL‐6 pathway observed in cells might represent an adaptive mechanism to senescence, but preserving some specific cellular functions, including immunosuppression, in SSc.
62
Concise Review: Hematopoietic Stem Cell Aging, Life Span, and Transplantation
Gary Van Zant,Ying Liang +1 more
TL;DR: Understanding the biological changes in the aging of stem cells as well as local and systematic environments will improve the efficacy of aged stem cells for regenerative medicine and ultimately facilitate improved health and life spans.
60
Mechanobiological conditioning of mesenchymal stem cells for enhanced vascular regeneration.
Jason Lee,Kayla Henderson,Miles W. Massidda,Miguel Armenta-Ochoa,Byung Gee Im,Austin Veith,Bum Kyu Lee,Mijeong Kim,Pablo Maceda,Eun Yoon,Lara Samarneh,Mitchell Wong,Andrew K. Dunn,Jonghwan Kim,Aaron B. Baker +14 more
TL;DR: In this paper, a high-throughput screening of the combinatorial space of mechanical-strain level and of the presence of particular kinase inhibitors was carried out, and human mesenchymal stem cells can be mechanically and pharmacologically conditioned to enhance vascular regeneration in vivo.
59
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