Aggressive variants of follicular cell-derived thyroid carcinoma: an overview

TL;DR: In this article , the molecular genetics of 22 patients with DSPTC were analyzed using Sanger sequencing and a gene panel next-generation sequencing (NGS) to characterize the genomic landscape of these tumors.

TL;DR: In this paper , a 56-year-old Japanese woman with Papillary thyroid carcinoma (PTC) showed characteristic histological features of a predominantly fused follicular and focally solid (FFS) pattern.

TL;DR: Age, tumor size, capsular invasion, and multifocality are independent risk factors for the development of LNM in DSV-PTC patients and the nomogram model can predict the risk of developing LNM in DSV-PTC patients and provide clinical guidance.

TL;DR: In this paper , the most aggressive forms of PTC include diffuse sclerosing, tall cell, and insular variants of thyroid cancer, and the highest frequency of BRAF V600E among PTC is shown by the high-cell variant of PCT (90%), also significantly higher with ''shoe nail» cells than in classical PTC and varies from 40-90%.

TL;DR: In this article, the authors describe the epidemiology, diagnosis, and management of PDTC and report their single centre experience to add to the limited evidence existing in the literature, which has important prognostic and therapeutic significance.

TL;DR: In this article, the authors re-evaluate the histopathological and clinicopathological features of 28 patients with SVPTC in the light of current literature and show that the tumor cells had characteristic nuclear features of conventional PTC, such as widespread angioinvasion, extrathyroidal extension, lymph node metastasis, and distant organ metastasis.

TL;DR: Tumors from the USA and from Italy showed similar overall survival, although the prevalence of poorly differentiated carcinoma was higher in Northern Italy, and the risk of death was higher for age ≥45, tumors ≥4 cm, and IMP3 positivity.

TL;DR: Aggressive surgery in patients with poorly differentiated thyroid cancer showing gross ETE resulted in satisfactory locoregional control, and the majority of patients who presented with or subsequently developed distant metastases eventually died of distant disease.