Patent
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Rodney E. Phillips,Peter Roderick Dunbar,Vincenzo Cerundolo,Andrew K. Sewell +3 more
- 04 Oct 2000
TL;DR: The authors concerne des complexes peptidiques de MHC ou des derives de ceux-ci, pouvant se lier, de maniere specifique, a des recepteurs de lymphocytes T a des temperatures beaucoup plus elevees qu'auparavant.
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Abstract: L'invention concerne des complexes peptidiques de MHC ou des derives de ceux-ci, pouvant se lier, de maniere specifique, a des recepteurs de lymphocytes T a des temperatures beaucoup plus elevees qu'auparavant. L'invention concerne egalement des agents actifs lies a ces complexes, ou a des derives de ceux-ci, pouvant etre internalises par des lymphocytes T.
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Use of Fluorogenic Histocompatibility Leukocyte Antigen-A*0201/HPV 16 E7 Peptide Complexes to Isolate Rare Human Cytotoxic T-Lymphocyte- recognizing Endogenous Human Papillomavirus Antigens
Sarah Jane Youde,P R Dunbar,E. M. L. Evans,Alison Nina Fiander,L. K. Borysiewicz,Vincenzo Cerundolo,Stephen Man +6 more
TL;DR: A tetramer consisting of HLA-A*0201 and the best studied HPV CTL peptide epitope, HPV 16 E711-20, provided a powerful tool to isolate polyclonal and clonal peptide-specific CTLs from an established HPV 16E7,11-21-20- specific CTL line and may be useful for selecting rare high-affinity HPV-specificCTLs for the immunotherapy of CaCx.
Peptides fused to the amino-terminal end of diphtheria toxin are translocated to the cytosol.
TL;DR: The results are compatible with a model in which the COOH-terminus of the A-fragment first crosses the membrane, whereas the NH2-terminal region follows behind, and neither hydrophobic nor highly charged sequences blocked translocation.
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Delivery of Antigens to the MHC Class I Pathway Using Bacterial Toxins
TL;DR: Of the toxins studied-diphtheria, pertussis, Pseudomonas, and anthrax-the anthrax toxin appears the most promising in its ability to deliver large protein antigens and its efficiency of translocation.
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Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes.
Graham S. Ogg,P R Dunbar,Vincenzo Cerundolo,Andrew J. McMichael,Nicholas R. Lemoine,Philip Savage +5 more
TL;DR: The powerful effector mechanisms of cytotoxic T-cells with the specificity of mAb are linked by targeting recombinant HLA class I molecules to tumour cells using an antibody delivery system, and this system could prove a new strategy for the immunological therapy of cancer.