Journal Article10.1038/S41582-019-0244-7
Ageing as a risk factor for neurodegenerative disease.
Yujun Hou,Xiuli Dan,Mansi Babbar,Yong Wei,Steen G. Hasselbalch,Deborah L. Croteau,Vilhelm A. Bohr,Vilhelm A. Bohr +7 more
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TL;DR: Hallmarks of ageing — genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication — correlate with susceptibility to neurodegenerative disease.
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Abstract: Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD). One in ten individuals aged ≥65 years has AD and its prevalence continues to increase with increasing age. Few or no effective treatments are available for ageing-related neurodegenerative diseases, which tend to progress in an irreversible manner and are associated with large socioeconomic and personal costs. This Review discusses the pathogenesis of AD, PD and other neurodegenerative diseases, and describes their associations with the nine biological hallmarks of ageing: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion and altered intercellular communication. The central biological mechanisms of ageing and their potential as targets of novel therapies for neurodegenerative diseases are also discussed, with potential therapies including NAD+ precursors, mitophagy inducers and inhibitors of cellular senescence.
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Citations
Evidence of sex differences in cellular senescence
Michael Ng,Lili-Naz Hazrati +1 more
TL;DR: A recent review as mentioned in this paper summarizes evidence of sex differences in cellular senescence-highlighting findings from both human and animal studies-and briefly discusses the potential relevance of sex chromosome epigenetics and mosaicism.
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Riccardo Goldoni,C Dolci,Elisa Boccalari,Francesco Inchingolo,Alessandro Paghi,Lucanos Marsilio Strambini,Daniela Galimberti,Gianluca M. Tartaglia +7 more
TL;DR: In this paper , the salivary analysis is used for the diagnosis of neurodegenerative and demyelinating diseases related to aging, such as Alzheimer's, Parkinson's, Amyotrophic Lateral Sclerosis, Huntington's disease, Multiple Sclerosis and multiple sclerosis.
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H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway
Lin Wei,Xiaowen Yang,Jie Wang,Zhixiao Wang,Qiguang Wang,Yan Ding,Aiqing Yu +6 more
TL;DR: This study quantified the levels of lactic acid in senescent microglia, and hippocampus tissues of naturally aged mice and AD mice models, and demonstrated that enhanced H3K18la directly stimulates the NFκB signaling pathway by upregulating senescence-associated secretory phenotype (SASP) components IL-6 and IL-8.
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Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances
Md. Abdul Hannan,Raju Dash,M. M. Haque,Md. Mohibbullah,Abdullah Al Mamun Sohag,Md. Ataur Rahman,Jamal Uddin,Mahboob Alam,Il Soo Moon +8 more
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TL;DR: The pathophysiology of neurodegenerative diseases and brain injuries is outlined, the literature on the neuroprotective potentials of algal compounds along with the underlying pharmacological mechanism is reviewed, and a rational strategy is proposed to facilitate algal metabolites-based drug development.
Phenomic Studies on Diseases: Potential and Challenges
TL;DR: Wang et al. as mentioned in this paper proposed a framework for the regulatory and ethical guidelines for phenomic studies on diseases, and developed effective international cooperation for phenomics-based studies on human diseases.
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