Journal Article10.1038/S41582-019-0244-7
Ageing as a risk factor for neurodegenerative disease.
Yujun Hou,Xiuli Dan,Mansi Babbar,Yong Wei,Steen G. Hasselbalch,Deborah L. Croteau,Vilhelm A. Bohr,Vilhelm A. Bohr +7 more
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TL;DR: Hallmarks of ageing — genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication — correlate with susceptibility to neurodegenerative disease.
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Abstract: Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD). One in ten individuals aged ≥65 years has AD and its prevalence continues to increase with increasing age. Few or no effective treatments are available for ageing-related neurodegenerative diseases, which tend to progress in an irreversible manner and are associated with large socioeconomic and personal costs. This Review discusses the pathogenesis of AD, PD and other neurodegenerative diseases, and describes their associations with the nine biological hallmarks of ageing: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion and altered intercellular communication. The central biological mechanisms of ageing and their potential as targets of novel therapies for neurodegenerative diseases are also discussed, with potential therapies including NAD+ precursors, mitophagy inducers and inhibitors of cellular senescence.
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Citations
Contribution of Extracellular Vesicles and Molecular Chaperones in Age-Related Neurodegenerative Disorders of the CNS
Leila Noori,Kamil P. Filip,Zohreh Nazmara,Simin Mahakizadeh,Gholamreza Ghassanzadeh Hassanzadeh,Celeste Caruso Bavisotto,Fabio Bucchieri,Antonella Marino Gammazza,Francesco Cappello,Maciej Wnuk,Federica Scalia +10 more
TL;DR: Extracellular Vesicles (EVs) are tiny membranous structures produced by a wide range of cells under physiological and pathological conditions, suggesting their significant role in fundamental processes particularly in cellular communication as mentioned in this paper .
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Changcheng Wang,Jin Kong,Xiao-Yue Li,Jin-Yue Yang,Changhu Xue,Teruyoshi Yanagita,Yuming Wang +6 more
TL;DR: Findings revealed that the sea-derived Antarctic krill oil combined with land-derived nobiletin (Nob) and L-theanine (The) may be an effective strategy to treat and alleviate AD.
Neuropathology and cholinesterase expression in the brains of octogenarians and older.
TL;DR: In this paper , a subset of octogenarians and older maintain normal cognitive function (CNOO) despite high prevalence and incidence of cognitive decline attributed to neurodegeneration or aging in the population.
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Hypothesis and Theory: Characterizing Abnormalities of Energy Metabolism Using a Cellular Platform as a Personalized Medicine Approach for Alzheimer's Disease.
TL;DR: In this paper, a cellular platform consisting of skin fibroblasts derived from LOAD patients and AD-unaffected control individuals was used to study LOAD pathogenic processes in context of age, disease, genetic background, cell development, and cell type.
Cell Death-Osis of Dopaminergic Neurons and the Role of Iron in Parkinson's Disease.
TL;DR: The molecular mechanisms underlying the activation of apoptosis, necroptosis and ferroptosis in PD are described and the efficacy of therapeutic approaches against neuronal death might depend on the death program they target and the relevance of this death pathway on a specific PD phase.
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