Journal Article10.1080/10837450.2018.1484766
Advances in rectal drug delivery systems.
104
TL;DR: Novel rectal drug delivery systems including hollow-type suppositories, thermo-responsive and muco-adhesive liquid suppository, and nanoparticulate systems incorporated into an appropriate vehicle have offered more control over delivery of drug molecules for local or systemic actions.
read more
Abstract: Drug delivery via the rectum is a useful alternative route of administration to the oral route for patients who cannot swallow. Traditional rectal dosage forms have been historically used for localized treatments including delivery of laxatives, treatment of hemorrhoids and for delivery of antipyretics. However, the recent trend is showing an increase in the development of novel rectal delivery systems to deliver drug directly into the systemic circulation by taking advantage of porto-systemic shunting. The present review is based on research studies carried out between years 1969-2017. Data for this review have been derived from keyword searches using Scopus and Medline databases. Novel rectal drug delivery systems including hollow-type suppositories, thermo-responsive and muco-adhesive liquid suppositories, and nanoparticulate systems incorporated into an appropriate vehicle have offered more control over delivery of drug molecules for local or systemic actions. In addition, various methods for in vitro-in vivo evaluation of rectal drug delivery systems are covered which is as important as the formulation, and must be carried out using appropriate methodology. Continuous research and development in this field of drug delivery may unleash the hidden potential of the rectal drug delivery systems.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
•Journal Article
Gray's Anatomy
TL;DR: The book will undoubtedly be considered a classical contribution to medical literature and is strongly recommended, not only because of the general interest of its topic, but as a reference book on penicillin therapy of hitherto unequalled excellence.
2.1K
Фізична реабілітація під час захворювань серцево-судинної системи в учнів 17 років
Наталія Грейда,Оксана Грицай,N. Hreida,O. Hrytsai +3 more
- 01 Jan 2010
TL;DR: The efficiency estimation of the developed author's program for high school students with diseases of the cardiovascular system physical fitness correction by means of physical rehabilitation is made in the article as mentioned in this paper, where the authors made an evaluation of the effectiveness of the program.
Biomedical applications of hydrogels in drug delivery system: An update
TL;DR: The motive behind this review is to highlight the key concept of hydrogels, their fabrication methods, stimuli-responsive polymers used for their fabrication, and their diverse utilization in the delivery system.
170
Physiological and Pharmaceutical Considerations for Rectal Drug Formulations.
TL;DR: This review will address the physiological and pharmaceutical considerations influencing rectal drug delivery as well as the conventional and novel drug delivery approaches.
Foundations of gastrointestinal-based drug delivery and future developments.
TL;DR: In this article, the authors examine the fundamentals of gastrointestinal drug delivery and discuss the challenges that need to be overcome for successful drug formulation, and describe the unique features to consider for each gastrointestinal compartment when designing drug formulations for topical and systemic applications.
118
References
An overview of the FDA publication Approved Drug Products with Therapeutic Equivalence Evaluations.
TL;DR: The history, purpose, and content of FDA's Approved Drug Products with Therapeutic Equivalence Evaluations (the "Orange Book") are described, and indexes by product name and manufacturer are included.
Effect of different bile salts on the relative hypoglycemia of Witepsol W35 suppositories containing insulin in diabetic beagle dogs
TL;DR: A relative hypoglycemia of about 50% can be reached using insulin suppositories containing Witepsol W35 as a base and NaDC plus NaC (100 mg plus 50 mg, respectively), NaTDC (100mg), or NaTC as rectal absorption enhancers of insulin.
Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository
TL;DR: In this article, the authors developed a novel in situ-gelling and mu-coadhesive acetaminophen liquid suppository with gelation temperature at 30-36°C and suitable gel strength and bioadhesive force.
•Book
Pharmaceutics - Dosage Form and Design
David S. Jones
- 01 Jan 2008
TL;DR: Pharmaceutic-dosage form and design, Pharmaceutic Dosage Form and Design (PDF) as discussed by the authors, is a generic form of dosage form and formulation.
Treating repetitive seizures with a rectal diazepam formulation A randomized study
James J. Cereghino,Wendy G. Mitchell,Jerome V. Murphy,Robert L. Kriel,W. E. Rosenfeld,Edwin Trevathan +5 more
TL;DR: A single rectal dose of Diastat was significantly more effective than placebo in reducing the number of seizures following an episode of ARS, suggesting that caregivers could administer treatment safely and effectively in a nonmedical setting.