Journal Article10.1016/J.BIOMATERIALS.2020.119827
Advances in nanomaterials for photodynamic therapy applications: Status and challenges.
Jianming Chen,Taojian Fan,Zhongjian Xie,Qiqiao Zeng,Ping Xue,Tingting Zheng,Yun Chen,Luo Xiaoling,Han Zhang +8 more
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TL;DR: The up-to-date advances in the fabrication and fascinating applications of various nanomaterials in PDT have been summarized, including various types of nanoparticles, carbon-based nanommaterials, and two-dimensional nanmaterials, etc.
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About: This article is published in Biomaterials. The article was published on 27 Jan 2020.
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Citations
Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions
José Higino Correia,José Higino Correia,José Alberto Rodrigues,Sara Pimenta,Tao Dong,Tao Dong,Zhaochu Yang +6 more
TL;DR: A review of the principles, mechanisms, photosensitizers, and current applications of photodynamic therapy can be found in this paper, where the future path on the research of new photosensizers with enhanced tumor selectivity, featuring the improvement of PDT effectiveness has also been addressed.
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Conquering the Hypoxia Limitation for Photodynamic Therapy
TL;DR: In this article, a review of the recent progress in new nanomaterials designed to combat hypoxia and avoid the associated limitation of photodynamic therapy (PDT) is presented.
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Recent Advances in Hyperthermia Therapy-Based Synergistic Immunotherapy.
TL;DR: The synergistic mechanism of HTT in immunotherapy, including immunogenic cell death and reversal of the immunosuppressive tumor microenvironment is discussed, and these strategies could achieve synergistically enhanced therapeutic outcomes against both primary tumors and metastatic lesions, prevent cancer recurrence, and prolong the survival period.
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Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy
Bin Ji,Minjie Wei,Bin Yan +2 more
TL;DR: The emerging nanomedicine-based strategies could subtly modulate the pharmacokinetics of therapeutic compounds and the TME to optimize both PDT and immunotherapy, resulting in an improved antitumor effect, and highlights the synergistic nanotherapeutics used to amplify immune responses combined with immunotherapy against tumors.
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Nanozymes-recent development and biomedical applications
TL;DR: Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed with the catalytic reactions of natural enzymes as discussed by the authors , which can be regulated by multiple factors, such as the chemical state of metal ion, pH, hydrogen peroxide (H2O2), and glutathione (GSH) level.
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References
Recent advancements in 2D nanomaterials for cancer therapy
TL;DR: In this article, the authors summarized recent progress on the design and fabrication of functional 2D nanomaterials capable of being applied for the cancer treatment including drug delivery, photodynamic therapy, and photothermal therapy.
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Sequential Protein-Responsive Nanophotosensitizer Complex for Enhancing Tumor-Specific Therapy.
Xingshu Li,Xingshu Li,Huanhuan Fan,Tian Guo,Huarong Bai,Nahyun Kwon,Kwang H. Kim,Sungsook Yu,Yejin Cho,Hyunji Kim,Ki Taek Nam,Juyoung Yoon,Xiao-Bing Zhang,Weihong Tan +13 more
TL;DR: A sequential protein-responsive aPS that is based on zinc(II) phthalocyanine derivative (PcC4)-entrapped mesoporous silica nanoparticles (MSNs) and a wrapping DNA (O1) as a biogate is developed that displays selective phototoxicity against cancer cells.
57
Tetra-n-propylporphycene as a tumour localizer: pharmacokinetic and phototherapeutic studies in mice.
TL;DR: Since TPP has a large absorbance in the 630-640 nm region, can be synthesized with a high degree of purity and is an efficient generator of singlet oxygen, this drug represents a potential candidate as a phototherapeutic agent for tumours.
55
X-ray radiation-induced and targeted photodynamic therapy with folic acid-conjugated biodegradable nanoconstructs
TL;DR: The cytotoxic effect caused by VP offers the possibility of enhancing the radiation therapy commonly prescribed for the treatment of cancer by simultaneous PDT by enhanced PDT efficacy compared with the radiation alone.
Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy
Kaplan Kirakci,Jaroslav Zelenka,Michaela Rumlová,Jiří Martinčík,Jiří Martinčík,Martin Nikl,Tomáš Ruml,Kamil Lang +7 more
TL;DR: The results demonstrate that the cluster-based radiosensitizers of O2(1Δg) have strong potential with respect to the enhancement of the efficacy of radiotherapy with exciting opportunities for cancer treatment.
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