Journal Article10.1152/AJPRENAL.00007.2005
Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms.
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TL;DR: It is concluded that the early, highly significant renoprotection obtained with MSC is of considerable therapeutic promise for the cell-based management of clinical ARF.
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Abstract: Severe acute renal failure (ARF) remains a common, largely treatment-resistant clinical problem with disturbingly high mortality rates. Therefore, we tested whether administration of multipotent me...
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Citations
Angiomyogenesis for myocardial repair.
TL;DR: A combined stem-cell and gene-therapy approach of angiomyogenesis is expected to yield better results as compared with either of the approaches as a monotherapy.
Myogenic differentiation of primary myoblasts and mesenchymal stromal cells under serum-free conditions on PCL-collagen I-nanoscaffolds
Aijia Cai,Moritz Hardt,Paul Schneider,Rafael Schmid,Claudia Lange,Dirk Dippold,Dirk W. Schubert,Anja M. Boos,Annika Weigand,Andreas Arkudas,Raymund E. Horch,Justus P. Beier,Justus P. Beier +12 more
TL;DR: This study was able to myogenically differentiate mesenchymal stromal cells with myoblasts on PCL-collagen I-nanoscaffolds in a serum-free medium, applicable to future clinical applications since no xenogenous substances were used.
Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells.
Christian Sávio-Silva,Stephany Beyerstedt,Poliana E. Soinski-Sousa,Expedito Barbosa Casaro,Maria Theresa A. Balby-Rocha,Antônio Simplício-Filho,Jamille Alves-Silva,Erika B Rangel +7 more
TL;DR: More studies in humans are needed to reach a conclusion if autologous MSCs from DM2 individuals are effective for treatment of DM-related complications, and randomized and controlled trials considering the source, optimal cell number, and route of delivery in DM patients are further required.
Multipotent mesenchymal stromal cells express FoxP3: a marker for the immunosuppressive capacity?
Mikael Sundin,Padraig D'Arcy,C. Christian Johansson,A. John Barrett,Helena Lönnies,Berit Sundberg,Silvia Nava,Rolf Kiessling,Dimitrios Mougiakakos,Katarina Le Blanc +9 more
TL;DR: The importance of FoxP3 in MSC-mediated immunosuppression was investigated by siRNA technology and mixed lymphocyte culture (MLC), and the first demonstration ofFoxP3 expression by MSCs is demonstrated.
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Review article: Endothelial progenitor cells in renal disease
TL;DR: The concept was attempted to promote attributes to the incompetence of endothelial progenitor cells in failed regeneration and ensuing progression of chronic kidney disease.
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References
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Bone marrow cells regenerate infarcted myocardium
Donald Orlic,Jan Kajstura,Stefano Chimenti,Igor Jakoniuk,Stacie M. Anderson,Baosheng Li,James Pickel,Ronald D.G. McKay,Bernardo Nadal-Ginard,David M. Bodine,Annarosa Leri,Piero Anversa +11 more
TL;DR: It is indicated that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease.
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Human mesenchymal stem cells modulate allogeneic immune cell responses
TL;DR: Insight is offered into the interactions between allogeneic MSCs and immune cells and mechanisms likely involved with the in vivo MSC-mediated induction of tolerance that could be therapeutic for reduction of GVHD, rejection, and modulation of inflammation.
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Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial
Kai C. Wollert,Gerd Peter Meyer,Joachim Lotz,Stefanie Ringes Lichtenberg,Peter Lippolt,Christiane Breidenbach,Stephanie Fichtner,Thomas Korte,Burkhard Hornig,Diethelm Messinger,Lubomir Arseniev,Bernd Hertenstein,Arnold Ganser,Helmut Drexler +13 more
TL;DR: Intracoronary transfer of autologous bone-marrow-cells promotes improvement of left-ventricular systolic function in patients after acute myocardial infarction.
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