Adjuvant effects on poly I poly C in New Zealand mice.
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TL;DR: These studies suggest that the New Zealand mice are already maximally stimulated to respond to SRBC and that additional adjuvant cannot augment their response.
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Abstract: The effects of polyinosinic polycytidylic acid (poly l poly C), a known adjuvant, were studied in New Zealand and C57B1/6 mice, using sheep erythrocytes (SRBC) as antigens. The control C57B1/6 mice showed a 3.1 to 6.7 fold increase in plaque forming cells (PFC) to SRBC when poly l poly C was given with the SRBC. The New Zealand mice (NZB/NZW F1 hybrids) showed very little increase in PFC with the poly l poly C. These studies suggest that the New Zealand mice are already maximally stimulated to respond to SRBC and that additional adjuvant cannot augment their response.
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158
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Identification of arthritogenic adjuvants of self and foreign origin.
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Human B cell function in a polyclonally induced plaque forming cell system. Cell triggering and immunoregulation.
TL;DR: The use of PBAs as probes and sensitive PVC systems as assays has already proven fruitful in the dissection of the complex mechanisms of nonspecific B cell triggering in man and may indeed ultimately lead to an understanding of the mechanisms of specificity of immune reactivity.
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References
Further implication of murine leukemia-like virus in the disorders of nzb mice
TL;DR: The collective findings implicate murine leukemia-like virus in the etiology of autoimmune hemolytic disease and membranous glomerulonephritis, as well as malignant lymphoma, of NZB mice and suggest that virus-specified cell-surface and soluble antigen is a factor in the immunopathogenesis of the renal disease and possibly also the autoimmune hemologic disease.
Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice.
Parker J. Staples,Norman Talal +1 more
TL;DR: Immunologic tolerance to ultracentrifuged bovine gamma globulin could not be induced in 6-wk old NZB or B/W mice, but developed readily in C3H, NZW, and C57Bl mice, which may be related to the lack of self-tolerance, autoimmunity, and lymphomas that develop in these mice at a later age.
The pathogenesis of autoimmunity in new zealand mice, i. induction of antinucleic acid antibodies by polyinosinic·polycytidylic acid
TL;DR: The results suggest that double-stranded RNA functions as a potent antigen in New Zealand mice, and a similar pathogenetic mechanism may be operative in some humans with systemic lupus erythematosus.
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•Journal Article
Strain differences in the immune response of mice: I. The neonatal response to sheep red cells
TL;DR: Neonatal mice of the inbred strains NZB, Balb/c and C57B1 were injected with sheep, pig or chicken red cells at various ages and antibody plaque-forming cell responses in their spleens measured, arguing that the thymus must be present for strain-specific immune responses to develop.
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The role of NZB-NZW F1 thymus in experimental tolerance and auto-immunity.
TL;DR: The role of the NZB/NZW F1 (B/W) thymus was studied with respect to tolerance to ultracentrifuged bovine γ globulin (BGG) and poly I· poly C, and spontaneous anti-DNA antibody formation and it is suggested that the adult B/WThymus may be functionally deficient relative to the young thymuses.
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