Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial.
Julien Freitag,D. Bates,James Wickham,Kiran Shah,Leesa Huguenin,Abi Tenen,Kade L. Paterson,Richard L. Boyd +7 more
266
TL;DR: Autologous ADMSC therapy appears to be a safe and effective therapy for knee osteoarthritis and may have the potential to prevent disease progression.
read more
Abstract: Aim: To evaluate the efficacy of autologous adipose-derived mesenchymal stem cell (ADMSC) therapy on pain, function and disease modification in knee osteoarthritis. Methods: 30 participants with symptomatic knee osteoarthritis were randomized into three groups. Two treatment groups received intra-articular ADMSC therapy consisting of either a single injection (100 × 106 ADMSCs) or two injections (100 × 106 ADMSCs at baseline and 6 months). The third group served as control and continued conservative management. Results: No serious adverse events were observed. Both treatment groups receiving ADMSCs showed clinically significant pain and functional improvement at completion of follow-up at 12 months. Radiological analysis using the Magnetic Resonance Imaging Osteoarthritis Knee Score indicated modification of disease progression. Conclusion: Autologous ADMSC therapy appears to be a safe and effective therapy for knee osteoarthritis and may have the potential to prevent disease progression. Trial registration number: ACTRN12614000814673.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations.
Dragan Primorac,Vilim Molnar,Eduard Rod,Željko Jeleč,Fabijan Čukelj,Vid Matišić,Trpimir Vrdoljak,Damir Hudetz,Hana Hajsok,Igor Borić +9 more
TL;DR: All of the latest and most important research in basic sciences, pathogenesis, and non-operative treatment of osteoarthritis is summarized.
365
Emerging pharmaceutical therapies for osteoarthritis.
TL;DR: The pathophysiological targets and clinical effects of new drugs currently being investigated for the treatment of osteoarthritis, along with relevant clinical data and discussion of the main challenges for the further development of these therapies are described to provide context for the latest advances in the field of pharmaceutical therapies for OA.
308
Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review
Ria Margiana,Alexander V. Markov,Angelina Olegovna Zekiy,Mohammed Ubaid Hamza,Khalid A. Al-Dabbagh,Sura Hasan Al-Zubaidi,Noora M. Hameed,Irshad Ahmad,R Sivaraman,Hamzah H. Kzar,Moaed E. Al-Gazally,Yasser Fakri Mustafa,Homayoon Siahmansouri +12 more
TL;DR: In this article , the authors provided a brief overview of immunoregulatory characteristics and immunosuppressive activities of mesenchymal stem cells and discussed the enhancement, utilization and therapeutic responses of MSCs in neural, liver, kidney, bone, heart diseases, and wound healing.
Systematic review of randomised controlled trials
Alison Avenell,Clare Robertson,Zoe Skea,Elisabet Jacobsen,Dwayne Boyers,David Cooper,Magaly Aceves-Martins,Lise Retat,Cynthia Fraser,Paul Aveyard,Fiona Stewart,Graeme MacLennan,Laura Elaine Irene Webber,Emily Corbould,Benshuai Xu,Abbygail Jaccard,Bonnie Boyle,Eilidh Duncan,Michal Shimonovich,Marijn de Bruin +19 more
- 01 Nov 2018
TL;DR: Specific interventions searched for were smoking cessation, dietary change, exercise, weight loss, blood-pressure control and cholesterol-lowering, as well as textwords including 'prevention' and 'multiple risk factor'.
144
Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients.
Christopher J. Rogers,Robert J. Harman,Bruce A. Bunnell,Martin A. Schreiber,Charlie Xiang,Fu Sheng Wang,Antonio F. Santidrian,Boris Minev +7 more
TL;DR: Adipose-derived stem cells (ASC), an abundant type of MSC, are proposed as a therapeutic option for the treatment of COVID-19 in order to reduce morbidity and mortality and when proven to be safe and effective, ASC treatments may reduce the demand on critical hospital resources.
References
Epidemiology of osteoarthritis: an update
Sakeba N. Issa,Leena Sharma +1 more
TL;DR: Predictors of function decline in osteoarthritis include lower self-efficacy, knee laxity, less aerobic exercise, worse joint proprioception, and greater knee pain.
263
Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series.
TL;DR: Autologous mesenchymal stem cell injection, in conjunction with hyaluronic acid, platelet rich plasma and calcium chloride, is a promising minimally invasive therapy for osteonecrosis of femoral head and, with low-dose dexamethasone, for osteoarthritis of human knees.
Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO): Platelet-Rich Plasma and Mesenchymal Stem Cells.
TL;DR: Minimum reporting requirements for clinical studies evaluating PRP and MSCs are developed using Delphi consensus methods and expert consensus on the inclusion of each item within minimum reporting guidelines is established.
225
•Journal Article
Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee.
TL;DR: Results suggest that one possible mechanism of action of viscosupplementation is to promote endogenous HA production in patients with mild to moderate knee OA following IA Hylan GF-20 injection.
199
Cartilage and meniscal T2 relaxation time as non-invasive biomarker for knee osteoarthritis and cartilage repair procedures
Thomas Baum,Gabby B. Joseph,Dimitrios C. Karampinos,Pia M. Jungmann,Thomas M. Link,Jan S. Bauer +5 more
TL;DR: It was demonstrated that cartilage and meniscal T2 relaxation time values were significantly increased in subjects with compared to those without radiographic OA and focal knee lesions, respectively, indicating that T1 relaxation time may be a reliable discriminatory biomarker.
196
Related Papers (5)
Yves-Marie Pers,Lars Rackwitz,Rosanna Ferreira,Oliver Pullig,Christophe Delfour,Frank Barry,Luc Sensebé,Louis Casteilla,Sandrine Fleury,Philippe Bourin,Danièle Noël,François Canovas,C. Cyteval,Gina Lisignoli,Joachim H. X. Schrauth,Daniel Haddad,Sophie Domergue,Ulrich Noeth,Christian Jorgensen +18 more