Journal Article10.1080/14653240310003026
Adipose-derived adult stem cells: isolation, characterization, and differentiation potential
Jeffrey M. Gimble,Farshid Guilak +1 more
1.2K
TL;DR: Adipose tissue is an abundant, accessible, and replenishable source of adult stem cells that can be isolated from liposuction waste tissue by collagenase digestion and differential centrifugation, and these ADAS cells have potential applications for the repair and regeneration of acute and chronically damaged tissues.
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About: This article is published in Cytotherapy. The article was published on 01 Jan 2003. The article focuses on the topics: Stem cell transplantation for articular cartilage repair & Adult stem cell.
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Citations
Engineered Fat Graft Enhanced with Adipose-Derived Stromal Vascular Fraction Cells for Regenerative Medicine: Clinical, Histological and Instrumental Evaluation in Breast Reconstruction.
TL;DR: The use of EF-e-A was safe and effective in this series of treated cases and a restoration of the breast contour and an increase in the three-dimensional volume after 12 weeks was observed.
107
Human multipotent adipose-derived stem cells restore dystrophin expression of Duchenne skeletal-muscle cells in vitro.
Natássia M. Vieira,V. Brandalise,Eder Zucconi,Tatiana Jazedje,Mariane Secco,Viviane Abreu Nunes,Bryan E. Strauss,Mariz Vainzof,Mayana Zatz +8 more
TL;DR: ASCs (adipose‐derived stem cells) are able to restore dystrophin expression in the muscles of mdx (X‐linked muscular dystrophy) mice, however, the outcome when these cells interact with human dystrophic muscle is still unknown.
104
Differential gene expression in adipose stem cells cultured in allogeneic human serum versus fetal bovine serum.
Bettina Lindroos,Kaisa-Leena Aho,Hannu Kuokkanen,Sari Räty,Heini Huhtala,Riina Lemponen,Olli Yli-Harja,Riitta Suuronen,Susanna Miettinen +8 more
TL;DR: How allogeneic HS (alloHS) performs in ASC expansion compared to FBS is defined, where early osteogenic differentiation was significantly enhanced in FBS, and the importance of thorough investigation of ASCs for utilization in cell therapies is underscore.
Adipose tissue engineering with cells in engineered matrices.
TL;DR: This article reviews the key progress to date in the field of adipose tissue engineering using a cell-seeded scaffold approach, where engineered extracellular matrix substitutes are seeded with exogenous cells that may contribute to the regenerative response.
101
Multipotency and growth characteristic of periosteum-derived progenitor cells for chondrogenic, osteogenic, and adipogenic differentiation.
Yong-Soo Choi,Sang-Eun Noh,Sang-Min Lim,Chang-Woo Lee,Chul-Soo Kim,Moon Whan Im,Moon Hee Lee,Dong-Il Kim +7 more
TL;DR: A rapid method for the isolation of PDPCs that can differentiate into mesodermal lineages and provide enough cells in a short period of time for allogeneic cell therapy is developed.
101
References
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Multilineage cells from human adipose tissue: implications for cell-based therapies.
Patricia A. Zuk,Min Zhu,Hiroshi Mizuno,Jerry I. Huang,Futrell Jw,Adam J. Katz,Prosper Benhaim,H. P. Lorenz,Marc H. Hedrick +8 more
TL;DR: The data support the hypothesis that a human lipoaspirate contains multipotent cells and may represent an alternative stem cell source to bone marrow-derived MSCs.
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Patricia A. Zuk,Min Zhu,Peter Ashjian,Daniel A. De Ugarte,Jerry I. Huang,Hiroshi Mizuno,Zeni Alfonso,John K. Fraser,Prosper Benhaim,Marc H. Hedrick +9 more
TL;DR: To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.
The Metabolism of Isolated Fat Cells: I. Effects of Hormones on Glucose Metabolism and Lipolysis
Martin Rodbell
- 01 Feb 1964
TL;DR: This article marks the beginning of Rodbell's interest in cell receptors and related his discovery that fat cells could be isolated from other cells by treating them with preparations of collagenase, and also found that insulin could stimulate glucose uptake.
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