Journal Article10.1038/NM788
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Toshimasa Yamauchi,Junji Kamon,Yasuhiko Minokoshi,Yoichi M. Ito,Hironori Waki,S. Uchida,Shigeo Yamashita,Mitsuhiko Noda,Shunbun Kita,K Ueki,Koji Eto,Y. Akanuma,Philippe Froguel,Fabienne Foufelle,Pascal Ferré,David Carling,Shigeko Kimura,Ryozo Nagai,Barbara B. Kahn,Takashi Kadowaki +19 more
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TL;DR: It is shown that phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full- lengths Ad in the liver, indicating that stimulation of glucose utilization and fatty-acid oxidation by Ad occurs through activation of AMPK.
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Abstract: Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism. However, the signaling pathways that mediate the metabolic effects of Ad remain poorly identified. Here we show that phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full-length Ad in the liver. In parallel with its activation of AMPK, Ad stimulates phosphorylation of acetyl coenzyme A carboxylase (ACC), fatty-acid oxidation, glucose uptake and lactate production in myocytes, phosphorylation of ACC and reduction of molecules involved in gluconeogenesis in the liver, and reduction of glucose levels in vivo. Blocking AMPK activation by dominant-negative mutant inhibits each of these effects, indicating that stimulation of glucose utilization and fatty-acid oxidation by Ad occurs through activation of AMPK. Our data may provide a novel paradigm that an adipocyte-derived antidiabetic hormone, Ad, activates AMPK, thereby directly regulating glucose metabolism and insulin sensitivity in vitro and in vivo.
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Citations
Ameliorative effects of stabilized rice bran on type 2 diabetes patients.
Hsing Hsien Cheng,Hsin Yi Huang,Ya Yen Chen,Chen Ling Huang,Chun Jen Chang,Hsiao Lien Chen,Ming Hoang Lai +6 more
TL;DR: It is demonstrated that stabilized rice bran can lower the level of HbA1c and blood lipids and increase blood adiponectin concentrations in type 2 diabetic subjects.
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Adiponectin and adiponectin receptor genes are coexpressed during zebrafish embryogenesis and regulated by food deprivation.
Shin-ichi Nishio,Yann Gibert,Laure Bernard,Frédéric Brunet,Gérard Triqueneaux,Vincent Laudet +5 more
TL;DR: It is observed that adiponectin B expression in adult liver is reduced while the expression of the receptors is increased in fasted fish, indicating that the upstream members of the Adip onectin pathway have complex expression patterns and are regulated by food deprivation in zebrafish.
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Effect of weight loss on markers of triglyceride-rich lipoprotein metabolism in the metabolic syndrome
TL;DR: The effect of weight loss by dietary restriction on markers of triglyceride‐rich lipoprotein (TRL) metabolism and plasma adipocytokines is determined.
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Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases.
Ying Liu,Vivian Vu,Gary Sweeney +2 more
TL;DR: The effects and mechanism of action of adiponectin on cardiometabolic tissues are reviewed, scenarios where enhancing adiponECTin action would be of clinical value are identified and approaches via which this can be achieved are discussed.
Food Polyphenols and Type II Diabetes Mellitus: Pharmacology and Mechanisms
TL;DR: In this paper , the authors present an overview of the most recent developments in using food polyphenols for managing and treating type II diabetes mellitus, along with various mechanisms, and evaluate their potential as complementary or alternative medicines to treat type II Diabetes mellitus.
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