Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/β-Catenin Pathways
Lulu Farhana,Marcia I. Dawson,Jayanta Kumar Das,Farhan Murshed,Farhan Murshed,Zebin Xia,Timothy Hadden,James S. Hatfield,Joseph A. Fontana +8 more
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Identification of Pancreatic Cancer Stem Cells
Chenwei Li,David G. Heidt,Piero Dalerba,Charles F. Burant,Lanjing Zhang,Volkan Adsay,Max S. Wicha,Michael F. Clarke,Diane M. Simeone +8 more
TL;DR: This work identified a highly tumorigenic subpopulation of pancreatic cancer cells expressing the cell surface markers CD44, CD24, and epithelial-specific antigen (ESA) that showed the stem cell properties of self-renewal, the ability to produce differentiated progeny, and increased expression of the developmental signaling molecule sonic hedgehog.
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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
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Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer
Patrick C. Hermann,Stephan Huber,Tanja Herrler,Alexandra Aicher,Joachim W. Ellwart,Markus Guba,Christiane J. Bruns,Christopher Heeschen +7 more
TL;DR: It is demonstrated that a subpopulation of migrating CD133(+) CX CR4(+) cancer stem cells is essential for tumor metastasis and strategies aimed at modulating the SDF-1/CXCR4 axis may have important clinical applications to inhibit metastasis of cancer stem Cells.
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Identification of pancreatic cancer stem cells
TL;DR: This work identified a highly tumorigenic subpopulation of pancreatic cancer cells expressing the cell surface markers CD44, CD24, and epithelial-specific antigen (ESA) that showed the stem cell properties of self-renewal, the ability to produce differentiated progeny, and increased expression of the developmental signaling molecule sonic hedgehog.
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