Journal Article10.1056/NEJM199902113400607
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Cem Gabay,Irving Kushner +1 more
6.7K
TL;DR: A large number of changes, distant from the site or sites of inflammation and involving many organ systems, may accompany inflammation, and the mechanisms mediating them are becoming better understood.
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Abstract: A large number of changes, distant from the site or sites of inflammation and involving many organ systems, may accompany inflammation. In 1930 interest was focused on these changes by the discovery of C-reactive protein (so named because it reacted with the pneumococcal C-polysaccharide) in the plasma of patients during the acute phase of pneumococcal pneumonia.1 Accordingly, these systemic changes have since been referred to as the acute-phase response,2 even though they accompany both acute and chronic inflammatory disorders. New acute-phase phenomena continue to be recognized, and the mechanisms mediating them are becoming better understood. This review summarizes much of . . .
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Citations
Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men.
Rachel Lampert,J. Douglas Bremner,Shaoyong Su,Andrew H. Miller,Forrester A. Lee,Faiz A. Cheema,Jack Goldberg,Viola Vaccarino +7 more
TL;DR: C-reactive protein is associated with decreased HRV, even after controlling for traditional CAD risk factors, and Autonomic dysregulation leading to inflammation may represent one pathway through which traditional risk factors promote development of CAD.
240
Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: striking similarities and obvious differences with mammals.
Bin Lin,Shangwu Chen,Zhen Cao,Yiqun Lin,Dunzhou Mo,Haibo Zhang,Juda Gu,Meiling Dong,Zehuan Liu,Anlong Xu +9 more
TL;DR: The first systematic study of zebrafish immune response to Aeromonas salmonicida and Staphylococcus aureus is presented, implying evolutionary conserved mechanisms among fish and mammals.
239
Inflammatory markers and cardiovascular health in older adults.
TL;DR: It is possible that, in older age-groups, interventions designed to prevent cardiovascular disease through the modulation of inflammation would also be helpful in reducing disability and mortality.
Perinatal depression—The fourth inflammatory morbidity of pregnancy?: Theory and literature review
Lauren M. Osborne,Catherine Monk +1 more
TL;DR: In this article, the theoretical background of inflammation in perinatal depression was reviewed and the literature concerning immune and inflammatory factors in the etiology and course of PPD was reviewed.
237
High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes.
TL;DR: The inhibition of LPS effects by high concentrations of LBP in acute-phase serum, as described here, may represent a novel defense mechanism of the host in severe sepsis and during bacterial infections.
236
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