Journal Article10.1053/J.GASTRO.2007.01.055
Acute Pancreatitis: Bench to the Bedside
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About: This article is published in Gastroenterology. The article was published on 01 Mar 2007. The article focuses on the topics: Acute pancreatitis.
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Citations
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
TL;DR: The concept of neutrophils phenotypic and functional heterogeneity is presented and several neutrophil subpopulations reported to date are described and the role these sub Populations seem to play in homeostasis and disease is discussed.
Organ failure and infection of pancreatic necrosis as determinants of mortality in patients with acute pancreatitis.
Maxim S. Petrov,Satyanarayan T. Shanbhag,Mandira Chakraborty,Anthony R. J. Phillips,John A. Windsor +4 more
TL;DR: In patients with acute pancreatitis, the absolute influence of OF and IPN on mortality is comparable and thus the presence of either indicates severe disease and the relative risk of mortality doubles when of both are both present.
831
Lactated Ringer's solution reduces systemic inflammation compared with saline in patients with acute pancreatitis.
Bechien U. Wu,James Q. Hwang,Timothy H. Gardner,Kathryn Repas,Ryan Delee,Song Yu,Benjamin N. Smith,Peter A. Banks,Darwin L. Conwell +8 more
TL;DR: Patients with acute pancreatitis who were resuscitated with lactated Ringer's solution had reduced systemic inflammation compared with those who received saline.
536
Interventions for necrotizing pancreatitis: summary of a multidisciplinary consensus conference.
Martin L. Freeman,Jens Werner,Hjalmar C. van Santvoort,Todd H. Baron,Marc G. Besselink,John A. Windsor,Karen D. Horvath,Eric vanSonnenberg,Thomas L. Bollen,Santhi Swaroop Vege +9 more
TL;DR: Intervention is primarily indicated for infected necrosis, less often for symptomatic sterile necrotizing pancreatitis, and should ideally be delayed as long as possible, preferably 4 weeks or longer after the onset of disease, for better demarcation and liquefaction of the necrosis.
424
Effective and safe proton pump inhibitor therapy in acid-related diseases - A position paper addressing benefits and potential harms of acid suppression
TL;DR: Overall, PPIs are irreplaceable drugs in the management of acid-related diseases, however, PPI treatment, as any kind of drug therapy, is not without risk of adverse effects.
References
CCK-JMV-180, an analog of cholecystokinin, releases intracellular calcium from an inositol trisphosphate-independent pool in rat pancreatic acini
TL;DR: Investigation of the source and mechanism of Ca2+ release induced by CCK-JMV-180 using streptolysin O-permeabilized pancreatic acinar cells indicates that it stimulates release of Ca 2+ from a hitherto uncharacterized intracellular storage pool which is insensitive to either IP3 or caffeine.
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Tumor-induced acute pancreatitis.
TL;DR: There are now three case reports of bronchogenic carcinoma metastatic to the pancreas causing acute pancreatitis, and in the present case, there was histological evidence of rupture of pancreatic ducts by tumor and obstruction ofducts by nests of tumor cells.
66
Ethanol sensitizes NF-κB activation in pancreatic acinar cells through effects on protein kinase C-ε
Akihiko Satoh,Anna S. Gukovskaya,Joseph R. Reeve,Tooru Shimosegawa,Stephen J. Pandol,Stephen J. Pandol +5 more
TL;DR: This work has demonstrated that in vitro ethanol treatmen treat pancreatitis by blocking the action of alcohol on the pancreas through the actions of EMT and “cell reprograming”.
64
Effect of hyperthermia on NF-κB binding activity in cerulein-induced acute pancreatitis
TL;DR: The results suggest that hyperthermia decreases the severity of cerulein-induced pancreatitis by decreasing cytokine expression in the pancreas through the modulation of NF-kappaB activity.
Alcohol and zymogen activation in the pancreatic acinar cell.
TL;DR: To examine the ability of alcohols to sensitize the acinar cell to CCK, the conversion of zymogens to active enzymes in isolated acini was assayed and alcohols, including 35 mmol/L ethanol, sensitized acini toCCK induced activation.
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