Acute Pancreatitis: Bench to the Bedside

TL;DR: In patients with acute pancreatitis, the absolute influence of OF and IPN on mortality is comparable and thus the presence of either indicates severe disease and the relative risk of mortality doubles when of both are both present.

TL;DR: Patients with acute pancreatitis who were resuscitated with lactated Ringer's solution had reduced systemic inflammation compared with those who received saline.

TL;DR: Intervention is primarily indicated for infected necrosis, less often for symptomatic sterile necrotizing pancreatitis, and should ideally be delayed as long as possible, preferably 4 weeks or longer after the onset of disease, for better demarcation and liquefaction of the necrosis.

TL;DR: Overall, PPIs are irreplaceable drugs in the management of acid-related diseases, however, PPI treatment, as any kind of drug therapy, is not without risk of adverse effects.

TL;DR: The results using this in vitro system support the hypothesis that the appearance of active trypsin within the pancreas during the early stages of cerulein-induced pancreatitis reflects activation oftrypsinogen by the lysosomal hydrolase cathepsin B.

TL;DR: Electron microscopic immunolabeling studies revealed localization of cathepsin D in discrete organelles that, in the samples from animals infused with a supramaximally stimulating dose of caerulein, were larger, more abundant, and more concentrated in the pellet centrifuged at 1,300 g for 15 min than in the controls.

TL;DR: It is suggested that Bax and Bak may not operate in precisely the same manner and the current models for their function are evaluated.

TL;DR: Although severity of necrotizing pancreatitis was somewhat increased in extended pancreatic necrosis and infected necrosis, mortality was more strongly linked to organ failure at admission and multiple organ failure during hospitalization.